Gene: TLCD3A
Official Full Name: TLC domain containing 3Aprovided by HGNC
Gene Summary: The protein encoded by this gene is a membrane-associated protein that promotes lung carcinogenesis. The encoded protein may be involved in amino acid transport and glutathione metabolism since it can interact with a solute carrier family member (SLC3A2) and an isoform of gamma-glutamyltranspeptidase-like 3. An alternatively spliced variant encoding a protein that lacks a 32 aa internal segment showed the opposite effect, inhibiting lung cancer cell growth. Knockdown of this gene also inhibited lung carcinogenesis and tumor cell growth. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13387 | TLCD3A Knockout cell line (HeLa) | Human | TLCD3A | 1:3~1:6 | Negative | Online Inquiry |
KO13388 | TLCD3A Knockout cell line (HCT 116) | Human | TLCD3A | 1:2~1:4 | Negative | Online Inquiry |
KO13389 | TLCD3A Knockout cell line (HEK293) | Human | TLCD3A | 1:3~1:6 | Negative | Online Inquiry |
KO13390 | TLCD3A Knockout cell line (A549) | Human | TLCD3A | 1:3~1:4 | Negative | Online Inquiry |
TLCD3A Gene Knockout Cell Lines are specially developed cellular models designed to lack the expression of the TLCD3A gene, a critical component implicated in various cellular processes, including immune response modulation and pathogen interaction. These cell lines provide researchers with a powerful tool to study the functional role of TLCD3A in various biological contexts, enabling deeper insights into its contributions to health and disease.
The primary function of TLCD3A Gene Knockout Cell Lines is to facilitate the investigation of gene function through the complete absence of the target gene. They operate on the principle of gene editing, utilizing CRISPR/Cas9 technology to achieve precise knockout of TLCD3A. This allows for rigorous assessments of cellular characteristics in a controlled environment, providing clarity on TLCD3A's impact on signaling pathways, cell proliferation, differentiation, and apoptosis. By examining the differences in cellular behavior between wild-type and TLCD3A knockout lines, researchers can elucidate the gene's role in various pathologies, including autoimmune diseases and cancer.
Scientifically, these cell lines are crucial for advancing our understanding of gene function and regulation. In research settings, they serve as models for drug screening and the development of therapeutic strategies, while in clinical contexts, they aid in identifying potential biomarkers for disease progression and treatment response. This contributes to the growing body of knowledge aimed at personalizing medicine and enhancing patient care.
What sets TLCD3A Gene Knockout Cell Lines apart from alternative systems is their high specificity and reproducibility, which ensure that the data generated is both reliable and relevant. By using a well-characterized model, researchers can confidently draw conclusions pertaining to the gene's involvement in specific biological activities.
For researchers, clinicians, and pharmaceutical companies alike, TLCD3A Gene Knockout Cell Lines represent an invaluable asset that streamlines experimental workflows and enhances the potential for impactful discoveries. Our company, with its extensive expertise in genetic engineering and cell line development, is committed to providing high-quality biological products that empower scientific research and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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