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TIMM23B Knockout Cell Lines

Gene: TIMM23B

Official Full Name: translocase of inner mitochondrial membrane 23 homolog Bprovided by HGNC

Gene Summary: Predicted to enable protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13396 TIMM23B Knockout cell line (HeLa) Human TIMM23B 1:3~1:6 Negative Online Inquiry
KO13397 TIMM23B Knockout cell line (HCT 116) Human TIMM23B 1:2~1:4 Negative Online Inquiry
KO13398 TIMM23B Knockout cell line (A549) Human TIMM23B 1:3~1:4 Negative Online Inquiry

Background

TIMM23B Gene Knockout Cell Lines are genetically modified cellular models designed for the precise investigation of the TIMM23B gene, a pivotal component of mitochondrial protein import and metabolism. These cell lines are engineered to facilitate the study of mitochondrial dysfunction, thereby providing insights into various metabolic disorders and potential therapeutic pathways.

The primary function of TIMM23B involves the translocation of preproteins across the mitochondrial inner membrane, playing a critical role in mitochondrial biogenesis and function. By utilizing CRISPR/Cas9 technology, our TIMM23B Knockout Cell Lines completely abrogate the expression of the TIMM23B gene, allowing researchers to explore the resulting phenotypic changes, cellular pathways, and the interplay between mitochondrial and cellular homeostasis. This knockout model can serve as a crucial tool for understanding the mechanisms of diseases linked to mitochondrial dysfunction, such as neurodegenerative disorders and metabolic syndromes.

The scientific importance of these cell lines extends to various applications within research and clinical settings. They provide a robust platform for drug discovery, testing the efficacy of therapeutic compounds targeting mitochondrial pathways, and facilitating investigations into the mechanisms of mitochondrial diseases. Furthermore, these knockouts serve as valuable comparative models in studies assessing mitochondrial dynamics and cellular energy metabolism.

What sets our TIMM23B Gene Knockout Cell Lines apart from alternative models is their high specificity and complete gene removal, ensuring reliable and reproducible experimental outcomes. Unlike other models that may present ambiguous results due to partial gene knockdown, our cell lines offer a clean slate for researchers to draw definitive conclusions about TIMM23B functions.

For researchers and clinicians looking to deepen their understanding of mitochondrial biology and its implications for human health, these cell lines are indispensable tools that enhance the quality and efficiency of scientific inquiry. Our commitment to excellence in producing high-quality biological products, coupled with our expert team, ensures that you have access to the most reliable models that cater to your research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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