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THBS3 Knockout Cell Lines

Gene: THBS3

Official Full Name: thrombospondin 3provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10137 THBS3 Knockout cell line (HeLa) Human THBS3 1:3~1:6 Negative Online Inquiry
KO10138 THBS3 Knockout cell line (HCT 116) Human THBS3 1:2~1:4 Negative Online Inquiry
KO10139 THBS3 Knockout cell line (HEK293) Human THBS3 1:3~1:6 Negative Online Inquiry
KO10140 THBS3 Knockout cell line (A549) Human THBS3 1:3~1:4 Negative Online Inquiry

Background

THBS3 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the Thrombospondin-3 (THBS3) gene. These cell lines serve as crucial tools for understanding the biological role of THBS3 in various physiological and pathological processes. Through the utilization of targeted CRISPR/Cas9 technology, these knockout cell lines provide researchers with a reliable means to study the effects of THBS3 deficiency on cellular functions, interactions, and signaling pathways.

The primary function of the THBS3 gene is to regulate cellular adhesion, migration, and the extracellular matrix organization, which are all key elements in processes such as tissue repair, angiogenesis, and tumor progression. By employing THBS3 Gene Knockout Cell Lines, researchers can explore the implications of THBS3 absence in different biological contexts, allowing for greater insight into conditions like cancer, fibrotic diseases, and cardiovascular disorders.

From a scientific perspective, these knockout cell lines are invaluable for preclinical studies where understanding gene functions can lead to novel therapeutic targets. They can be used in various applications, including drug discovery, mechanistic studies, and biomarker identification. Compared to traditional cell lines, which may still express THBS3 at variable levels, the THBS3 knockout lines present a clear and definitive model for gene function investigation.

One of the unique selling points of our THBS3 Gene Knockout Cell Lines is their robust validation and reproducibility, ensuring that results obtained are both reliable and translatable to clinical research. Additionally, they are designed for ease of use, allowing researchers to incorporate them seamlessly into existing experimental workflows.

For researchers and clinicians aiming to decipher the complexities of THBS3 in health and disease, these knockout cell lines represent a powerful asset that can accelerate the pace of discovery. With a focus on high-quality biotechnological solutions, our company is committed to providing exceptional products that advance research and support scientific excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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