Gene: TGIF1
Official Full Name: TGFB induced factor homeobox 1provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11451 | TGIF1 Knockout cell line (HeLa) | Human | TGIF1 | 1:3~1:6 | Negative | Online Inquiry |
KO11452 | TGIF1 Knockout cell line (HCT 116) | Human | TGIF1 | 1:2~1:4 | Negative | Online Inquiry |
KO11453 | TGIF1 Knockout cell line (HEK293) | Human | TGIF1 | 1:3~1:6 | Negative | Online Inquiry |
KO11454 | TGIF1 Knockout cell line (A549) | Human | TGIF1 | 1:3~1:4 | Negative | Online Inquiry |
TGIF1 Gene Knockout Cell Lines are a specialized biological product designed for cutting-edge molecular biology research. These cell lines are engineered to lack the TGIF1 gene, which is critically involved in various cellular processes, including embryonic development and tumorigenesis. The specific knockout of the TGIF1 gene allows researchers to study the functional consequences of its absence, providing insightful data into gene regulation mechanisms and their implications in health and disease.
The primary function of these knockout cell lines is to facilitate the investigation of the TGIF1 gene's role in signaling pathways, cell proliferation, and differentiation. By utilizing CRISPR/Cas9 gene-editing technology, these cell lines provide a highly efficient and precise method for gene disruption. Researchers can analyze phenotypic changes in response to TGIF1 loss, enabling the study of its involvement in cancer progression, developmental biology, and other relevant biological processes.
The scientific importance of TGIF1 Gene Knockout Cell Lines cannot be overstated, as they serve as valuable tools for elucidating the underlying mechanisms of disease and identifying potential therapeutic targets. In clinical research, these models can aid in drug screening, biomarker discovery, and understanding resistance mechanisms in targeted therapies, ultimately enhancing translational research efforts.
Compared to traditional gene-knockout methods, our TGIF1 Gene Knockout Cell Lines offer superior efficiency and specificity, minimizing off-target effects and enhancing reproducibility in experiments. Our product stands out due to rigorous validation, ensuring the integrity of genetic modifications and consistent performance across experimental conditions.
For researchers and clinicians, these cell lines represent an invaluable asset for advancing scientific knowledge and fostering innovation in therapeutics. The value of our TGIF1 Gene Knockout Cell Lines lies not only in their robust experimental utility but also in their capacity to bridge fundamental research with clinical applications.
At [Company Name], we leverage extensive expertise in genetic engineering and molecular biology to deliver high-quality biological products that empower scientists to make breakthrough discoveries in their fields.
Please note that all services are for research use only. Not intended for any clinical use.
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