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TGFBRAP1 Knockout Cell Lines

Gene: TGFBRAP1

Official Full Name: transforming growth factor beta receptor associated protein 1provided by HGNC

Gene Summary: This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02698 TGFBRAP1 Knockout cell line (HeLa) Human TGFBRAP1 1:3~1:6 Negative Online Inquiry
KO02699 TGFBRAP1 Knockout cell line (HCT 116) Human TGFBRAP1 1:2~1:4 Negative Online Inquiry
KO02700 TGFBRAP1 Knockout cell line (HEK293) Human TGFBRAP1 1:3~1:6 Negative Online Inquiry
KO02701 TGFBRAP1 Knockout cell line (A549) Human TGFBRAP1 1:3~1:4 Negative Online Inquiry

Background

TGFBRAP1 Gene Knockout Cell Lines are specialized cell lines that have undergone genetic modification to disrupt the TGFBRAP1 gene, which is involved in various cellular processes, including TGF-β signaling and cellular growth regulation. This knockout approach allows researchers to study the specific roles and functions of the TGFBRAP1 protein in both physiological and pathological contexts. By eliminating the expression of this gene, the cell lines provide a unique platform for investigating the mechanisms by which TGF-β pathways influence cellular behavior, including differentiation, apoptosis, and immune responses.

The key mechanisms facilitated by these knockout cell lines allow scientists to perform functional assays that illuminate how TGFBRAP1 regulates critical signaling cascades. Understanding these pathways is paramount for elucidating the underlying biological processes that contribute to diseases such as cancer, fibrosis, and other fibrotic diseases. The TGFBRAP1 knockout cell lines thus serve as a crucial tool in preclinical research, providing insights that may lead to the development of targeted therapies and interventions.

One of the unique selling points of TGFBRAP1 Gene Knockout Cell Lines is their ability to offer a specific model to study TGF-β signaling without the confounding effects of the TGFBRAP1 protein, which can influence cytotoxicity and other cellular responses. In contrast to alternative cell models, these knockout lines enable more precise manipulation and assessment of gene function, yielding reliable data for researchers seeking to unravel complex biological interactions.

For researchers and clinicians, the value of these cell lines is significant. They not only facilitate deeper understanding of crucial signaling pathways but also enhance the development of innovative therapies aimed at diseases where TGF-β plays a pivotal role. The ability to generate reproducible and relevant biological data makes these knockout cell lines an indispensable resource in both academic and clinical research settings.

Our company specializes in providing high-quality genetically modified cell lines that exemplify our commitment to advancing scientific research. With a strong foundation in molecular biology and a focus on fostering innovation, we are dedicated to supporting researchers in their quest to uncover new therapeutic avenues. The TGFBRAP1 Gene Knockout Cell Lines are a testament to our expertise and dedication to providing products that enhance the understanding of complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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