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TF Knockout Cell Lines

Gene: TF

Official Full Name: transferrinprovided by HGNC

Gene Summary: This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09939 TF Knockout cell line (HEK293) Human TF 1:3~1:6 Negative Online Inquiry
KO09940 TF Knockout cell line (A549) Human TF 1:3~1:4 Negative Online Inquiry

Background

TF Gene Knockout Cell Lines are sophisticated biological research tools designed to enable the systematic study of transcription factor (TF) function and their regulatory networks. These engineered cell lines are crafted through advanced CRISPR-Cas9 technology, which facilitates precise gene editing by creating specific knockout mutations in target genes associated with transcription factor activity. As a result, researchers can investigate the effects of losing a particular transcription factor on cellular behavior, gene expression profiles, and signaling pathways.

The core mechanism behind TF Gene Knockout Cell Lines revolves around their ability to provide a controlled environment for gene function analysis. By selectively deactivating specific transcription factors, scientists can discern the biological roles these proteins play in various processes, including cell growth, differentiation, and response to external stimuli. This insight is crucial in research areas such as cancer biology, developmental biology, and regenerative medicine, where transcription factors are often key regulators of tumor progression and cellular identity.

The scientific importance of these cell lines extends to both basic and applied research. In clinical settings, understanding the role of transcription factors can illuminate disease mechanisms and pave the way for targeted therapies. The ability to conduct loss-of-function studies in a reproducible and reliable manner positions TF Gene Knockout Cell Lines as indispensable tools for both academic and industrial laboratories aiming to innovate in drug development and personalized medicine.

What sets our TF Gene Knockout Cell Lines apart from alternatives is their high specificity and efficiency in gene editing, coupled with extensive validation provided by our development team. Our product features rigorous characterization and functional assays that ensure researchers are working with cell lines that truly represent the absence of the target transcription factor.

For researchers and clinicians delving into the complexities of gene regulation, TF Gene Knockout Cell Lines offer an unprecedented opportunity to uncover novel biological insights and therapeutic strategies. With our commitment to quality and innovation, backed by years of expertise in genetic engineering and molecular biology, [Your Company Name] stands at the forefront of advancing research and unlocking new potentials in the field of gene function exploration.

Please note that all services are for research use only. Not intended for any clinical use.

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