Gene: TESK1
Official Full Name: testis associated actin remodelling kinase 1provided by HGNC
Gene Summary: This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35047 | TESK1 Knockout cell line (HeLa) | Human | TESK1 | 1:3~1:6 | Negative | Online Inquiry |
KO35048 | TESK1 Knockout cell line (HCT 116) | Human | TESK1 | 1:2~1:4 | Negative | Online Inquiry |
KO35049 | TESK1 Knockout cell line (HEK293) | Human | TESK1 | 1:3~1:6 | Negative | Online Inquiry |
KO35050 | TESK1 Knockout cell line (A549) | Human | TESK1 | 1:3~1:4 | Negative | Online Inquiry |
TESK1 Gene Knockout Cell Lines are specialized cellular models engineered through the CRISPR-Cas9 technology to disrupt the function of the TESK1 gene, a serine/threonine kinase implicated in various cellular signaling pathways, including those that govern cell proliferation, migration, and repair mechanisms. These knockout cell lines serve as essential research tools for elucidating the specific roles of the TESK1 protein in health and disease, particularly in cancer biology and regenerative medicine.
The key function of TESK1 Gene Knockout Cell Lines is to enable researchers to study the consequences of TESK1 loss-of-function in controlled settings. By attenuating the gene's expression, scientists can observe changes in cellular behavior, signal transduction pathways, and the overall impact on cellular homeostasis. This knockout model provides invaluable insights into the molecular underpinnings of TESK1-related pathologies and assists in the identification of potential therapeutic targets.
In the realm of scientific research, these cell lines are pivotal. They are widely utilized in drug discovery processes, mechanistic studies, and patient-derived model systems that reflect in vivo conditions more effectively than traditional models. The availability of precise knockout models enhances the reproducibility of experiments, facilitating a more thorough understanding of gene function and its implications in various disease states.
Compared to traditional gene silencing methods, such as RNA interference (RNAi), which often yield transient effects, our TESK1 Gene Knockout Cell Lines provide complete and permanent gene disruption. This durability allows for extended study duration and more robust data collection, greatly benefiting experimental consistency and accuracy.
For researchers and clinicians focused on understanding the TESK1-related mechanisms and developing targeted therapies, these knockout lines represent a crucial investment. They offer a dependable platform for translational research that can drive discoveries from the bench to the bedside.
Our company specializes in producing advanced biological products, ensuring the highest standards of quality and reliability. We are committed to supporting the scientific community with innovative tools that enhance research capabilities and contribute to groundbreaking advancements in biotechnology and medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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