Gene: TENT5B
Official Full Name: terminal nucleotidyltransferase 5Bprovided by HGNC
Gene Summary: Enables poly(A) RNA polymerase activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of cell population proliferation; and positive regulation of translation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30606 | TENT5B Knockout cell line (HeLa) | Human | TENT5B | 1:3~1:6 | Negative | Online Inquiry |
KO30607 | TENT5B Knockout cell line (HCT 116) | Human | TENT5B | 1:2~1:4 | Negative | Online Inquiry |
KO30608 | TENT5B Knockout cell line (HEK293) | Human | TENT5B | 1:3~1:6 | Negative | Online Inquiry |
KO30609 | TENT5B Knockout cell line (A549) | Human | TENT5B | 1:3~1:4 | Negative | Online Inquiry |
TENT5B Gene Knockout Cell Lines are a set of genetically engineered cell lines designed to lack the expression of the TENT5B gene, which is involved in RNA methylation and post-transcriptional regulation. These cell lines serve as a powerful tool for researchers to dissect the functional roles of TENT5B in cellular processes such as apoptosis, stress response, and differentiation. By eliminating the functional expression of this gene, researchers can assess the downstream effects on cell behavior, signaling pathways, and overall cellular health.
The key mechanism of action involves the use of CRISPR/Cas9 technology or RNA interference to facilitate precise gene editing. This enables researchers to generate stable knockout cell lines that maintain the genetic alterations across multiple generations, ensuring consistent and reproducible results. The TENT5B Gene Knockout Cell Lines are invaluable in studying various biological processes and can lead to significant breakthroughs in understanding diseases where RNA modifications play a critical role, such as certain cancers and neurodegenerative disorders.
Scientific importance is underscored by their application in both research and clinical settings, where understanding the TENT5B gene's role could inform therapeutic strategies. The ability to precisely manipulate cellular pathways using these knockout lines positions them as essential components in drug discovery and development, particularly for targeted therapeutic approaches.
What sets the TENT5B Gene Knockout Cell Lines apart from other genetic tools is the robustness and specificity of the knockout. Unlike traditional knockdown strategies that may only temporarily reduce gene expression, these knockout lines offer a permanent solution, greatly enhancing the reliability of experiments. Additionally, their ease of use and compatibility with various screening assays make them suitable for high-throughput applications, offering users a time-efficient alternative.
For researchers and clinicians who demand high-quality, reproducible models to explore novel therapeutic targets and validate hypotheses, TENT5B Gene Knockout Cell Lines represent a vital asset. Our company, with its expertise in genome editing and commitment to advancing biological research, is dedicated to providing innovative tools that empower scientists to unravel complex biological questions and accelerate the pace of discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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