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TBXT Knockout Cell Lines

Gene: TBXT

Official Full Name: T-box transcription factor Tprovided by HGNC

Gene Summary: The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Variation in this gene was associated with susceptibility to neural tube defects and chordoma. A mutation in this gene was found in a family with sacral agenesis with vertebral anomalies. [provided by RefSeq, Sep 2018]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35152 TBXT Knockout cell line (HeLa) Human TBXT 1:3~1:6 Negative Online Inquiry

Background

TBXT Gene Knockout Cell Lines are a revolutionary genomic tool designed to facilitate the study of the TBXT gene, which encodes the T-box transcription factor involved in crucial developmental processes. These engineered cell lines are created through advanced CRISPR-Cas9 gene editing technology, resulting in a complete knockout of the TBXT gene. This allows researchers to investigate the biological roles of the TBXT protein in various cellular contexts without the confounding influence of TBXT expression.

The key function of TBXT Gene Knockout Cell Lines lies in their ability to model gene loss-of-function scenarios that are critical for understanding diseases and developmental disorders associated with TBXT malfunction. By providing a system that eliminates TBXT expression, these cell lines enable the elucidation of gene function through phenotypic analysis and the assessment of downstream signaling pathways. Researchers can utilize these cell lines in a variety of assays, including drug response studies, cellular differentiation investigations, and functional genomic screenings, thereby advancing our comprehension of not only the TBXT gene but also broader genetic interactions.

The scientific importance of TBXT Gene Knockout Cell Lines extends to applications in both basic research and clinical settings, including studies on congenital disorders such as spinal muscular atrophy and other pathologies linked to T-box genes. By utilizing this product, researchers can pursue novel therapeutic interventions and gain insights necessary for disease prevention and treatment strategies.

In comparison to alternative models, TBXT Gene Knockout Cell Lines offer several advantages, including high specificity, reproducibility, and the convenience of being ready-to-use for immediate experimentation. These knockout cell lines streamline the research workflow, eliminating the time-consuming steps associated with the conventional generation of knockout models, and can deliver more reliable data sensitive to the nuanced roles of the target gene.

Ultimately, TBXT Gene Knockout Cell Lines present a valuable asset for researchers and clinicians alike, enhancing their capacity to explore gene function with precision and integrative insight. Our company is dedicated to supporting scientific innovation with high-quality genomic products and has established a reputation for excellence and reliability in the field. By choosing our TBXT Gene Knockout Cell Lines, you are empowered to advance your research and contribute vital knowledge to the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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