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TBC1D1 Knockout Cell Lines

Gene: TBC1D1

Official Full Name: TBC1 domain family member 1provided by HGNC

Gene Summary: TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07421 TBC1D1 Knockout cell line (HeLa) Human TBC1D1 1:3~1:6 Negative Online Inquiry
KO07422 TBC1D1 Knockout cell line (HCT 116) Human TBC1D1 1:2~1:4 Negative Online Inquiry
KO07423 TBC1D1 Knockout cell line (HEK293) Human TBC1D1 1:3~1:6 Negative Online Inquiry
KO07424 TBC1D1 Knockout cell line (A549) Human TBC1D1 1:3~1:4 Negative Online Inquiry

Background

TBC1D1 Gene Knockout Cell Lines are specially engineered cell lines in which the TBC1D1 gene—known to play a crucial role in cellular signaling and metabolism—has been selectively disrupted. This knockout mechanism enables researchers to study the impact of TBC1D1 deficiency on cellular processes, particularly those related to glucose metabolism, insulin signaling, and cellular proliferation. The utility of these cell lines lies in their ability to elucidate the functional role of TBC1D1, offering insights into molecular pathways that could lead to advancements in treating metabolic disorders and obesity-related conditions.

The primary function of the TBC1D1 gene is to regulate the activity of the RAB family of small GTPases, which are essential for intracellular transport and signal transduction. By utilizing CRISPR-Cas9 gene editing technology, our TBC1D1 knockout cell lines facilitate rigorous examination of how the absence of this gene affects cellular behavior, making them valuable tools for both basic and applied research. Studies utilizing these lines have the potential to unlock new therapeutic targets for insulin resistance and type 2 diabetes, thus possessing significant clinical relevance.

What sets our TBC1D1 knockout cell lines apart from alternatives is the rigorous validation process they undergo, ensuring robust gene disruption and consistent performance across experiments, which is critical for replicable scientific research. Furthermore, our commitment to quality and customer support provides reassurance to researchers navigating the complexities of gene function analysis.

The value of TBC1D1 Gene Knockout Cell Lines lies in their ability to drive forward critical research that may have far-reaching implications in understanding and combating metabolic diseases. By providing a reliable model system, we empower researchers and clinicians to explore new horizons in the field of metabolic research. Our company, with its extensive expertise in developing advanced biological tools, stands ready to support research endeavors that push the boundaries of science and enhance human health.

Please note that all services are for research use only. Not intended for any clinical use.

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