Gene: TAB2
Official Full Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 2provided by HGNC
Gene Summary: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10987 | TAB2 Knockout cell line (HeLa) | Human | TAB2 | 1:3~1:6 | Negative | Online Inquiry |
KO10988 | TAB2 Knockout cell line (HCT 116) | Human | TAB2 | 1:2~1:4 | Negative | Online Inquiry |
KO10989 | TAB2 Knockout cell line (HEK293) | Human | TAB2 | 1:3~1:6 | Negative | Online Inquiry |
KO10990 | TAB2 Knockout cell line (A549) | Human | TAB2 | 1:3~1:4 | Negative | Online Inquiry |
TAB2 Gene Knockout Cell Lines are meticulously engineered cellular models that enable the study of the TAB2 gene, a critical component in the signaling pathways linked to cellular responses to stress and inflammation. By utilizing CRISPR/Cas9 technology to achieve precise gene disruption, these cell lines provide researchers with the ability to explore the functional consequences of TAB2 absence, thereby enhancing our understanding of its role in various biological processes.
The key functional mechanism of TAB2 Gene Knockout Cell Lines lies in their capacity to mimic a pathological state where TAB2 is absent. This facilitates the examination of downstream signaling effects, particularly in regard to pathways like NF-κB activation and MAP kinase signaling, which are integral in mediating responses to cytokines and environmental stresses. Such insights are crucial for elucidating the roles of TAB2 in disease states, including cancer and autoimmune disorders.
The scientific importance of these cell lines extends to both research and clinical applications, as they allow for the examination of therapeutic targets and mechanisms of disease. Researchers can utilize TAB2 Knockout Cell Lines for drug screening, functional genomics, and pathophysiological studies, fundamentally advancing knowledge in molecular biology and genetic engineering.
One significant advantage of TAB2 Gene Knockout Cell Lines is their high specificity and reliability for gene investigations compared to conventional methods of gene silencing, such as RNAi. With CRISPR/Cas9-mediated knockouts, researchers benefit from stable gene disruption, eliminating complications associated with transient knockdown strategies. This not only enhances experimental reproducibility but also provides a more accurate representation of gene function.
For researchers, clinicians, and biopharmaceutical companies alike, the value of TAB2 Gene Knockout Cell Lines lies in their capacity to drive the discovery of novel interventions and understand complex disease mechanisms. The ability to investigate gene function in a controlled environment is vital for advancing therapeutic development.
At [Company Name], we pride ourselves on our expertise in developing high-quality biological tools that empower the scientific community. Our TAB2 Gene Knockout Cell Lines are a testament to our commitment to providing reliable and innovative solutions for researchers striving to uncover the intricacies of cellular biology and pathology.
Please note that all services are for research use only. Not intended for any clinical use.
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