Gene: SYT12
Official Full Name: synaptotagmin 12provided by HGNC
Gene Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23399 | SYT12 Knockout cell line (HeLa) | Human | SYT12 | 1:3~1:6 | Negative | Online Inquiry |
KO23400 | SYT12 Knockout cell line (HCT 116) | Human | SYT12 | 1:2~1:4 | Negative | Online Inquiry |
KO23401 | SYT12 Knockout cell line (A549) | Human | SYT12 | 1:3~1:4 | Negative | Online Inquiry |
SYT12 Gene Knockout Cell Lines are sophisticated biological tools designed to facilitate the study of the SYT12 gene, an integral component in neurotransmitter release and synaptic function. These cell lines are generated using advanced CRISPR-Cas9 technology, allowing for precise genomic modifications that render the SYT12 gene inoperative. The resultant knockout model provides researchers with a powerful platform to investigate the physiological roles of SYT12 and its implications in various neurological disorders.
The primary function of these knockout cell lines involves enabling the exploration of the molecular mechanisms underlying synaptic activity. By eliminating the SYT12 gene, researchers can elucidate its specific roles in calcium-dependent exocytosis and synaptic vesicle dynamics, which are crucial for neurotransmission. This detailed understanding can pave the way for identifying potential therapeutic targets in conditions such as autism spectrum disorders or neurodegenerative diseases where synaptic dysfunction is a hallmark.
The scientific importance of SYT12 Gene Knockout Cell Lines is underscored by their diverse applications in both fundamental and translational research settings. They serve as valuable models for drug discovery, functional genomics, and the investigation of gene-environment interactions. The unique versatility of these models allows researchers to conduct high-throughput screening, making them invaluable in preclinical studies aimed at discovering new treatments.
Comparatively, SYT12 Gene Knockout Cell Lines stand out due to their precise genetic alterations, which offer a more targeted approach than traditional methods such as chemical inhibitors or less specific genetic manipulations. Their reproducibility and reliability enhance experimental outcomes, ensuring that researchers can obtain consistent results across different experimental setups.
For researchers and clinicians aiming to deepen their understanding of synaptic biology or to develop interventions for synaptic dysfunction, SYT12 Gene Knockout Cell Lines represent an indispensable asset. With an established track record in producing high-quality biological products, our company is committed to supporting scientific innovation through advanced cell line technologies. By choosing our SYT12 Gene Knockout Cell Lines, users gain access to unparalleled insights that drive forward research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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