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SUN1 Knockout Cell Lines

Gene: SUN1

Official Full Name: Sad1 and UNC84 domain containing 1provided by HGNC

Gene Summary: This gene is a member of the unc-84 homolog family and encodes a nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2019]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29397 SUN1 Knockout cell line (HeLa) Human SUN1 1:3~1:6 Negative Online Inquiry
KO29398 SUN1 Knockout cell line (HCT 116) Human SUN1 1:2~1:4 Negative Online Inquiry
KO29399 SUN1 Knockout cell line (HEK293) Human SUN1 1:3~1:6 Negative Online Inquiry
KO29400 SUN1 Knockout cell line (A549) Human SUN1 1:3~1:4 Negative Online Inquiry

Background

SUN1 Gene Knockout Cell Lines are specialized cellular models that facilitate the study of the SUN1 gene's function and its role in various biological processes. These cell lines are engineered through precise genetic editing techniques, such as CRISPR-Cas9, to disrupt the SUN1 gene, enabling researchers to investigate the resulting phenotypic consequences and pathways that are influenced by its absence.

The primary function of these cell lines is to provide a controlled environment in which the effects of SUN1 depletion can be analyzed. SUN1, a protein that plays a crucial role in nuclear anchoring and cellular signaling, is implicated in several biological phenomena, including nuclear shape regulation and chromosomal stability. By utilizing SUN1 knockout models, researchers can effectively discern the molecular mechanisms underlying these processes, paving the way for deeper insights into related diseases, including cancer and muscular dystrophies.

The scientific importance of SUN1 Gene Knockout Cell Lines is notable in both research and clinical applications. They serve as vital tools for elucidating gene function, screening potential drug targets, and understanding disease mechanisms. Furthermore, they can be used in gene therapy studies aimed at restoring normal function to the disrupted gene.

Compared to traditional cell lines, SUN1 knockout models offer unique advantages, such as enhanced specificity in targeting the SUN1 locus, reduced off-target effects, and the ability to elucidate the effects of gene loss in a highly relevant cellular context. This specificity allows for more accurate data and conclusions, ultimately leading to more effective research outcomes.

For researchers and clinicians, the value of SUN1 Gene Knockout Cell Lines lies in their potential to accelerate discoveries that could lead to innovative therapies. Their application not only contributes to basic biological understanding but also has far-reaching implications in translational research, including potential targets for therapeutic intervention in SUN1-associated disorders.

Our company prides itself on its state-of-the-art gene editing technologies and comprehensive support for researchers aiming to explore genetic and cellular questions. We are committed to advancing scientific knowledge and providing top-tier products that empower the scientific community to make groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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