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STXBP3 Knockout Cell Lines

Gene: STXBP3

Official Full Name: syntaxin binding protein 3provided by HGNC

Gene Summary: Enables syntaxin binding activity. Involved in negative regulation of calcium ion-dependent exocytosis; neutrophil degranulation; and platelet aggregation. Located in cytosol; plasma membrane; and secretory granule. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35185 STXBP3 Knockout cell line (HeLa) Human STXBP3 1:3~1:6 Negative Online Inquiry
KO35186 STXBP3 Knockout cell line (HCT 116) Human STXBP3 1:2~1:4 Negative Online Inquiry
KO35187 STXBP3 Knockout cell line (HEK293) Human STXBP3 1:3~1:6 Negative Online Inquiry
KO35188 STXBP3 Knockout cell line (A549) Human STXBP3 1:3~1:4 Negative Online Inquiry

Background

STXBP3 Gene Knockout Cell Lines are specialized cellular models that have undergone targeted gene editing to disrupt the expression of the STXBP3 gene. This gene encodes a protein that plays a pivotal role in the regulation of synaptic transmission and vesicular trafficking, influencing neuronal communication and other cellular processes. The knockout of STXBP3 provides researchers with a powerful tool to investigate the functional implications of this gene in various biological contexts, particularly in neurobiology and cellular signaling pathways.

These cell lines utilize standard CRISPR-Cas9 technology to achieve efficient gene disruption, allowing for precise manipulation of gene expression. By generating STXBP3 knockout models, researchers can explore the consequences of gene loss on synaptic function, neuronal morphology, and behavioral phenotypes, thereby clarifying the mechanisms underlying synaptic disorders and neurological diseases.

The scientific importance of STXBP3 knockout cell lines is underscored by their applications in both fundamental research and therapeutic development. They can aid in the identification of pathways affected by STXBP3 and serve as platforms for screening potential therapeutic interventions or pharmacological agents. Additionally, the ability to model disease states in vitro enhances the translational potential of findings into clinical settings.

One distinct advantage of these knockout cell lines is their ability to provide insights that would be challenging to assess using traditional methods, such as whole-animal models or non-specific knockdown techniques. They offer a controlled environment where variables can be meticulously managed, ensuring reproducibility and reliability in experimental outcomes.

For researchers and clinicians, leveraging STXBP3 gene knockout cell lines means access to a sophisticated and reliable model that enhances the understanding of synaptic function and its implications in health and disease. Our company is committed to providing high-quality biological products designed for cutting-edge research, backed by years of expertise in genetic engineering and cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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