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STX17 Knockout Cell Lines

Gene: Stx17

Official Full Name: syntaxin 17provided by MGI

Gene Summary: Predicted to enable SNAP receptor activity; SNARE binding activity; and enzyme binding activity. Predicted to be involved in several processes, including autophagosome maturation; endoplasmic reticulum to Golgi vesicle-mediated transport; and endoplasmic reticulum-Golgi intermediate compartment organization. Predicted to act upstream of or within protein localization to phagophore assembly site. Located in autophagosome. Is expressed in adrenal cortex. Orthologous to human STX17 (syntaxin 17). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00534 STX17 gRNA7-gRNA8 KO plasmid STX17 $850
GP00535 STX17 gRNA5-gRNA6 KO plasmid STX17 $850
KO33198 STX17 Knockout cell line (HeLa) Human STX17 1:3~1:6 Negative Online Inquiry
KO33199 STX17 Knockout cell line (HCT 116) Human STX17 1:2~1:4 Negative Online Inquiry
KO33200 STX17 Knockout cell line (HEK293) Human STX17 1:3~1:6 Negative Online Inquiry
KO33201 STX17 Knockout cell line (A549) Human STX17 1:3~1:4 Negative Online Inquiry

Background

Stx17 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to lack the syntaxin 17 (Stx17) gene, a critical component involved in the regulation of autophagy and intracellular trafficking. By eliminating the expression of this protein, researchers can directly study the downstream effects of Stx17 loss on cellular processes, thereby providing valuable insights into the underlying mechanisms governing autophagy-related diseases.

The primary mechanism by which Stx17 functions in the cell is as a SNARE (Soluble NSF Attachment Protein Receptor) protein, which facilitates membrane fusion events crucial for the autophagic pathway. This knockout model allows for the examination of altered autophagy dynamics, such as impaired cargo degradation and diminished cellular homeostasis, which are often implicated in neurodegenerative disorders, cancer, and various metabolic syndromes. Moreover, the Stx17 Gene Knockout Cell Lines can serve as an essential tool to elucidate novel drug targets and therapeutic strategies aimed at restoring normal autophagic function.

In the scientific community, the significance of utilizing specifically designed knockout models cannot be overstated. They provide researchers with a reliable and reproducible means to dissect complex biological phenomena at the molecular level, supporting investigations that explore gene function and interventional approaches in both basic and applied research contexts. Compared to traditional methods that may rely on pharmacological inhibitors or other indirect means, the Stx17 knockout cell lines offer a more precise and controlled way to study the implications of gene loss.

These cell lines stand out for their unparalleled specificity and availability, allowing for rapid adaptation in various experimental settings. This specificity significantly reduces background noise in experimental outcomes, leading to more reliable and interpretable data. Researchers and clinicians targeting autophagy and its associated pathways will find immense value in these cell lines as a foundational resource that enhances experimental rigor and accelerates the translation of laboratory findings to clinical paradigms.

Our company specializes in the development of high-quality biological products tailored to meet the rigorous demands of modern research. By offering Stx17 Gene Knockout Cell Lines, we empower the scientific community to explore critical biological processes with confidence and precision.

Please note that all services are for research use only. Not intended for any clinical use.

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