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STT3B Knockout Cell Lines

Gene: STT3B

Official Full Name: STT3 oligosaccharyltransferase complex catalytic subunit Bprovided by HGNC

Gene Summary: The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04812 STT3B Knockout cell line (HeLa) Human STT3B 1:3~1:6 Negative Online Inquiry
KO04813 STT3B Knockout cell line (HCT 116) Human STT3B 1:2~1:4 Negative Online Inquiry
KO04814 STT3B Knockout cell line (HEK293) Human STT3B 1:3~1:6 Negative Online Inquiry
KO04815 STT3B Knockout cell line (A549) Human STT3B 1:3~1:4 Negative Online Inquiry

Background

STT3B Gene Knockout Cell Lines are a cutting-edge biological tool designed to elucidate the function of the STT3B gene, which is pivotal in the processes of glycosylation and protein folding within the endoplasmic reticulum. These cell lines are engineered to lack the STT3B gene, enabling researchers to explore the gene's role in cellular mechanisms and its implications in various diseases, particularly those related to protein misfolding and associated pathologies.

The primary function of these knockout cell lines is to provide a controlled environment where the impact of the absence of STT3B can be meticulously analyzed. By utilizing CRISPR/Cas9 genomic editing techniques, these cell lines exhibit complete loss of STT3B activity, permitting a comprehensive investigation into how alterations in glycosylation patterns affect cell viability, signaling pathways, and protein interactions. This not only aids in fundamental biological research but also enhances our understanding of therapeutic targets in drug development and precision medicine.

The scientific importance of STT3B Gene Knockout Cell Lines is profound, with applications in both research and clinical settings. They serve as an invaluable resource for dissecting the molecular pathways involving glycosylation, opening avenues for studies focused on various diseases, including cancer and neurodegenerative disorders linked to protein aggregation. These lines also facilitate the screening of small molecules or biological agents that could rectify the protein folding issues associated with STT3B dysfunction.

Compared to alternative models, STT3B Gene Knockout Cell Lines stand out due to their specificity and precision. Traditional models may lack the nuanced genetic modification necessary for studying the gene's function, while these engineered lines provide a reliable and reproducible platform for hypothesis testing and validation. Additionally, their ease of use in standard laboratory settings and compatibility with high-throughput screening make them particularly advantageous for researchers pursuing time-sensitive studies.

In summary, the value of STT3B Gene Knockout Cell Lines extends beyond mere research applications; they represent a strategic tool for advancing our understanding of glycosylation-dependent diseases, delivering insights that could lead to transformative therapeutic strategies. Our company specializes in providing high-quality biological products and has a deep commitment to supporting researchers and clinicians with innovative tools that drive scientific discovery and improve health outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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