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STOM Knockout Cell Lines

Gene: STOM

Official Full Name: stomatinprovided by HGNC

Gene Summary: This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38022 STOM Knockout cell line (HeLa) Human STOM 1:3~1:6 Negative Online Inquiry
KO38023 STOM Knockout cell line (HCT 116) Human STOM 1:2~1:4 Negative Online Inquiry
KO38024 STOM Knockout cell line (HEK293) Human STOM 1:3~1:6 Negative Online Inquiry
KO38025 STOM Knockout cell line (A549) Human STOM 1:3~1:4 Negative Online Inquiry

Background

STOM Gene Knockout Cell Lines represent a significant advancement in genetic research, specifically engineered to enable the study of stomatin (STOM) gene function and its associated pathways in human cells. These cell lines are developed using CRISPR/Cas9 technology, resulting in precise deletions of the STOM gene, thus serving as a vital tool in dissecting the cellular roles of stomatin, which is implicated in various physiological processes, including membrane integrity, cell signaling, and mechanosensation.

The primary function of STOM Gene Knockout Cell Lines is to facilitate in-depth investigations into the impact of stomatin depletion on cellular behaviors, such as proliferation, differentiation, and apoptosis. The mechanism involves the introduction of targeted mutations that disrupt the normal protein expression, allowing researchers to observe the resultant phenotypic changes and identify STOM’s role in disease models.

Scientifically, these knockout cell lines are invaluable in biomedical research, offering insight into conditions like hereditary spherocytosis, hypertension, and certain types of cancer, where stomatin dysregulation plays a crucial role. Their application extends beyond basic research, providing a platform for the evaluation of new therapeutic strategies aimed at rectifying stomatin-related dysfunctions.

Compared to traditional knockout strategies, STOM Gene Knockout Cell Lines offer enhanced specificity and efficacy, reducing off-target effects and enhancing reproducibility. This advanced approach sets our product apart from alternatives that may lack precision or require cumbersome protocols.

For researchers and clinicians, the value of STOM Gene Knockout Cell Lines lies in their ability to drive innovative discoveries and accelerate the understanding of complex biological processes. By utilizing these cell lines, users can save time and resources while generating reliable data that can lead to significant breakthroughs in their research endeavors.

As a company, we pride ourselves on our commitment to advancing genetic research through high-quality, precision-engineered biological products. Our expertise in cell line development ensures that our offerings meet the rigorous standards necessary for impactful scientific research.

Please note that all services are for research use only. Not intended for any clinical use.

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