Home / STIP1 Knockout Cell Lines

STIP1 Knockout Cell Lines

Gene: STIP1

Official Full Name: stress induced phosphoprotein 1provided by HGNC

Gene Summary: STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02007 STIP1 Knockout cell line (HeLa) Human STIP1 1:3~1:6 Negative Online Inquiry
KO02008 STIP1 Knockout cell line (HCT 116) Human STIP1 1:2~1:4 Negative Online Inquiry
KO02009 STIP1 Knockout cell line (HEK293) Human STIP1 1:3~1:6 Negative Online Inquiry
KO02010 STIP1 Knockout cell line (A549) Human STIP1 1:3~1:4 Negative Online Inquiry

Background

STIP1 Gene Knockout Cell Lines represent a powerful tool for researchers focused on elucidating the biological functions and pathways associated with the STIP1 gene. These genetically engineered cell lines are created by targeted deletion of the STIP1 gene, a critical player in cellular stress response and protein folding processes, which encodes the stress-induced phosphoprotein 1. By removing this gene, researchers can investigate the consequential effects on cellular behavior, signaling pathways, and overall physiological responses, thus enabling a deeper understanding of cellular homeostasis and responses to external stressors.

The functionality of STIP1 Gene Knockout Cell Lines lies in their ability to serve as a versatile platform for various experimental approaches, including gene expression studies, drug sensitivity tests, and mechanistic investigations into signal transduction pathways. These cell lines provide insights into pathophysiological conditions where STIP1 may be implicated, facilitating the identification of novel therapeutic targets.

The significance of STIP1 Gene Knockout Cell Lines extends into both research and clinical applications. In research settings, they enable the dissection of STIP1's role in diseases, such as cancer and neurodegeneration, contributing to the overarching goal of precision medicine. Clinically, understanding STIP1's involvement in stress-related diseases may lead to innovative therapeutic strategies tailored to target these pathways effectively.

Compared to alternative models, including wild-type or less specific knockdown systems, STIP1 Gene Knockout Cell Lines offer enhanced specificity and clarity of results, allowing for more accurate elucidation of STIP1 function. Researchers benefit from robust reproducibility across studies, combined with the ability to easily integrate these knockout lines into broader experimental frameworks.

Given the continued importance of unraveling the complexities of gene function in health and disease, STIP1 Gene Knockout Cell Lines are invaluable assets for advancing scientific discovery. Our commitment to providing high-quality biological products, combined with our expertise in genetic engineering, positions us as a leader in this domain, ensuring researchers have access to state-of-the-art resources that propel their investigations forward.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.