Gene: ST6GALNAC4
Official Full Name: ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4provided by HGNC
Gene Summary: The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. Readthrough transcripts exist for this gene and the downstream ST6GALNAC6 gene. [provided by RefSeq, Jan 2022]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27847 | ST6GALNAC4 Knockout cell line (HeLa) | Human | ST6GALNAC4 | 1:3~1:6 | Negative | Online Inquiry |
KO27848 | ST6GALNAC4 Knockout cell line (HCT 116) | Human | ST6GALNAC4 | 1:2~1:4 | Negative | Online Inquiry |
KO27849 | ST6GALNAC4 Knockout cell line (HEK293) | Human | ST6GALNAC4 | 1:3~1:6 | Negative | Online Inquiry |
KO27850 | ST6GALNAC4 Knockout cell line (A549) | Human | ST6GALNAC4 | 1:3~1:4 | Negative | Online Inquiry |
ST6GALNAC4 Gene Knockout Cell Lines represent a significant advancement in genetic research, specifically focusing on the ST6GALNAC4 gene, which encodes a sialyltransferase involved in the biosynthesis of sialylated glycoproteins and glycolipids. These cell lines are engineered to lack functional ST6GALNAC4, providing a powerful tool for elucidating the biological functions of sialylation in cell signaling, immune modulation, and disease pathogenesis.
The primary function of these knockout cell lines is to facilitate studies on how the absence of ST6GALNAC4 affects cellular processes, including cell adhesion, migration, and differentiation, as well as their implications in cancer research and autoimmune disorders. By utilizing these cell lines, researchers can analyze the alterations in glycosylation patterns and their downstream effects on cellular activities, thereby elucidating novel pathways and potential therapeutic targets.
In addition to their utility in basic research, ST6GALNAC4 Gene Knockout Cell Lines hold significant promise in clinical applications, particularly in developing personalized medicine strategies. For example, understanding how sialylation influences drug responses and tumor progression can lead to more effective treatment modalities.
Compared to traditional cell lines, these knockout models offer unprecedented specificity and clarity in the study of ST6GALNAC4-related functions. They allow for more accurate modeling of diseases associated with aberrant glycosylation, thus enhancing the relevance of experimental findings to human physiology.
Researchers and clinicians will find these cell lines invaluable due to their ability to produce reproducible and interpretable results that could guide future therapeutic developments. Moreover, our company prides itself on its extensive expertise in genetic engineering and cell line development, ensuring that each product is optimized for quality and performance. By choosing ST6GALNAC4 Gene Knockout Cell Lines, users gain access to a robust research tool that addresses critical gaps in understanding sialylation's role in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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