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ST3GAL3 Knockout Cell Lines

Gene: ST3GAL3

Official Full Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 3provided by HGNC

Gene Summary: The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with a form of autosomal recessive nonsymdromic cognitive disability as well as infantile epileptic encephalopathy. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13714 ST3GAL3 Knockout cell line (HeLa) Human ST3GAL3 1:3~1:6 Negative Online Inquiry
KO13715 ST3GAL3 Knockout cell line (HCT 116) Human ST3GAL3 1:2~1:4 Negative Online Inquiry
KO13716 ST3GAL3 Knockout cell line (HEK293) Human ST3GAL3 1:3~1:6 Negative Online Inquiry
KO13717 ST3GAL3 Knockout cell line (A549) Human ST3GAL3 1:3~1:4 Negative Online Inquiry

Background

ST3GAL3 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate the study of the ST3GAL3 gene, which encodes a key enzyme involved in the biosynthesis of sialylated glycoproteins and glycolipids. By employing CRISPR/Cas9 gene editing technologies, these cell lines effectively disable the ST3GAL3 gene, allowing researchers to observe the resultant phenotypic changes and dissect the gene's functional role in cellular processes such as cell adhesion, signaling, and immune response.

The primary mechanism of action for these knockout cell lines involves the complete ablation of the ST3GAL3 gene, leading to a profound impact on the glycosylation patterns of surface proteins. This alteration is crucial for understanding the contributions of sialylation to various biological phenomena, including tumor progression and metastasis, as well as its influence on cell-cell interactions and immune escape mechanisms in cancer.

The scientific significance of ST3GAL3 Gene Knockout Cell Lines cannot be overstated, particularly in the context of cancer research and therapeutic development. These models serve as vital tools for elucidating the pathways governed by sialylation, ultimately paving the way for targeted therapies that can modify the glycosylation landscape of malignant cells.

What sets our ST3GAL3 Gene Knockout Cell Lines apart from other models is the precision of our CRISPR editing process, which guarantees high efficiency and specificity in gene knockout. This precision reduces the chances of off-target effects, creating a more reliable platform for research. Additionally, our extensive validation and characterization of these cell lines ensure consistency and reproducibility in experimental outcomes.

For researchers and clinicians aiming to unravel complex biological mechanisms or develop innovative therapeutic strategies, the value of our ST3GAL3 Gene Knockout Cell Lines is unmatched. With our commitment to quality and scientific rigor, we provide unparalleled support to enhance your research endeavors.

At [Your Company Name], we offer a range of cutting-edge tools and products, driven by expertise in gene editing and a dedication to advancing the frontiers of biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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