Gene: SRSF5
Official Full Name: serine and arginine rich splicing factor 5provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03456 | SRSF5 Knockout cell line (HeLa) | Human | SRSF5 | 1:3~1:6 | Negative | Online Inquiry |
KO03457 | SRSF5 Knockout cell line (HCT 116) | Human | SRSF5 | 1:2~1:4 | Negative | Online Inquiry |
KO03458 | SRSF5 Knockout cell line (HEK293) | Human | SRSF5 | 1:3~1:6 | Negative | Online Inquiry |
KO03459 | SRSF5 Knockout cell line (A549) | Human | SRSF5 | 1:3~1:4 | Negative | Online Inquiry |
SRSF5 Gene Knockout Cell Lines are specialized cellular models generated through the targeted disruption of the SRSF5 gene, a vital component involved in RNA splicing and post-transcriptional regulation. These cell lines provide scientists with the ability to study the gene's function and its role in cellular processes, particularly in the context of cancer biology and neurodevelopmental disorders. By utilizing CRISPR-Cas9 or similar gene-editing technologies, the SRSF5 gene is rendered inactive, leading to alterations in alternative splicing patterns, which can profoundly affect gene expression profiles within the cell.
The primary function of these knockout cell lines lies in their capacity to elucidate the molecular pathways influenced by SRSF5, thereby aiding researchers in understanding how aberrations in splicing contribute to various diseases. With the loss of SRSF5’s regulatory functions, researchers can investigate downstream effects including altered mRNA isoforms that may drive oncogenesis or impact neuronal function. This potential has made SRSF5 knockout cell lines crucial tools in both basic research and translational studies, paving the way for novel therapeutic strategies.
What sets our SRSF5 Gene Knockout Cell Lines apart from alternatives in the field is their high specificity and reproducibility. Meticulously validated through extensive characterization, these cell lines ensure consistent and reliable results, supporting the rigors of modern research. Furthermore, they are provided in a robust format compatible with high-throughput screening techniques, making them suitable for large-scale studies.
For researchers and clinicians dedicated to uncovering the complexities of gene regulation, our SRSF5 Gene Knockout Cell Lines represent a valuable asset, facilitating advancements in understanding disease mechanisms. As a company with a solid foundation in molecular biology and gene editing technologies, we pride ourselves on delivering high-quality products that empower scientists to make groundbreaking discoveries in their respective fields.
Please note that all services are for research use only. Not intended for any clinical use.
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