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SRR Knockout Cell Lines

Gene: SRR

Official Full Name: serine racemaseprovided by HGNC

Gene Summary: Enables several functions, including L-serine ammonia-lyase activity; PDZ domain binding activity; and heterocyclic compound binding activity. Involved in carboxylic acid metabolic process and response to lipopolysaccharide. Located in cytoplasm and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13735 SRR Knockout cell line (HeLa) Human SRR 1:3~1:6 Negative Online Inquiry
KO13736 SRR Knockout cell line (HCT 116) Human SRR 1:2~1:4 Negative Online Inquiry
KO13737 SRR Knockout cell line (HEK293) Human SRR 1:3~1:6 Negative Online Inquiry
KO13738 SRR Knockout cell line (A549) Human SRR 1:3~1:4 Negative Online Inquiry

Background

SRR Gene Knockout Cell Lines represent a groundbreaking tool in molecular biology, specifically designed to facilitate gene function studies by eliminating the expression of the SRR gene (serine racemase). These cell lines have been engineered using advanced CRISPR-Cas9 technology to ensure precise and efficient knockout of the SRR gene, which encodes an enzyme critical for converting L-serine to D-serine, a neurotransmitter implicated in synaptic plasticity and neurodevelopmental disorders.

The primary function of SRR Gene Knockout Cell Lines is to enable researchers to analyze the biological role of D-serine in neurotransmission and assess the physiological and pathological implications of altered serine metabolism. By studying these knockout models, scientists can gain insights into various neuropsychiatric diseases, including schizophrenia and Alzheimer’s, where D-serine levels are believed to contribute significantly to disease pathology. The mechanism involves using the deficiency in the SRR gene to elucidate downstream signaling pathways and receptor interactions that rely on D-serine, enhancing our understanding of synaptic functions.

This product holds significant scientific importance as it empowers both basic and applied research in neurobiology and pharmacology. In clinical research settings, these knockout cell lines can serve as critical components for drug discovery pipelines targeting SRR-related pathways, providing potential therapeutic avenues for neurodegenerative disorders.

What sets SRR Gene Knockout Cell Lines apart from conventional models is their precision, replicability, and the comprehensive support package that includes detailed protocols and troubleshooting assistance tailored for optimal experimental outcomes. Unlike earlier models that may have relied on chemical inhibitors or transient transfection methods, these knockout cell lines offer a stable and genetically defined platform for long-term studies, making them an invaluable asset in research labs.

For researchers and clinicians aiming to dissect the complex interactions in neurobiology and develop targeted therapies, SRR Gene Knockout Cell Lines represent a leap forward in experimental capabilities. With our company’s commitment to advancing biological research through innovative solutions and a rich portfolio of genetic tools, we ensure that you are equipped with the highest quality products to drive your investigations forward.

Please note that all services are for research use only. Not intended for any clinical use.

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