Gene: SREK1
Official Full Name: splicing regulatory glutamic acid and lysine rich protein 1provided by HGNC
Gene Summary: This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25521 | SREK1 Knockout cell line (HeLa) | Human | SREK1 | 1:3~1:6 | Negative | Online Inquiry |
KO25522 | SREK1 Knockout cell line (HCT 116) | Human | SREK1 | 1:2~1:4 | Negative | Online Inquiry |
KO25523 | SREK1 Knockout cell line (HEK293) | Human | SREK1 | 1:3~1:6 | Negative | Online Inquiry |
KO25524 | SREK1 Knockout cell line (A549) | Human | SREK1 | 1:3~1:4 | Negative | Online Inquiry |
SREK1 Gene Knockout Cell Lines represent a pioneering tool in molecular biology, specifically designed to facilitate the study of the SREK1 gene's function. This product consists of genetically engineered cell lines in which the SREK1 gene has been effectively inactivated or knocked out, allowing researchers to investigate the consequential biological pathways that this gene influences.
The key mechanism by which SREK1 knockout cell lines operate relies on CRISPR-Cas9 technology, a highly precise method for gene editing. By targeting the specific DNA sequences of the SREK1 gene, this technique introduces double-strand breaks, leading to gene disruption. This enables researchers to observe the resultant phenotypic changes, cellular behaviors, and biochemical pathways that may be affected by the absence of SREK1, thus providing vital insights into its role in cellular processes such as apoptosis, stress response, and oncogenesis.
In scientific research, SREK1 gene knockout cell lines are invaluable in elucidating the gene's function and its potential implications in various disease states, particularly those associated with metabolic dysregulation and cancer. These cell models are essential for drug discovery, target validation, and understanding therapeutic resistance mechanisms, making them indispensable tools in both basic and translational research settings.
Compared to traditional gene silencing methods, such as RNA interference, knockout cell lines provide a more robust and enduring deletion of the gene, thereby offering more reliable data on gene function over longer periods. Additionally, these cell lines can facilitate high-throughput screening applications, enabling researchers to expedite their investigations into the effects of different treatments on cellular responses.
For researchers and clinicians keen on exploring gene functions, developing therapeutics, or validating targets, SREK1 Gene Knockout Cell Lines offer unparalleled advantages in terms of efficiency, accuracy, and the depth of insight they provide into gene-related pathways. Furthermore, our commitment to quality and expertise in gene editing technologies ensures that our products meet the highest standards, empowering scientific breakthroughs and fostering innovation in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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