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SPINT2 Knockout Cell Lines

Gene: SPINT2

Official Full Name: serine peptidase inhibitor, Kunitz type 2provided by HGNC

Gene Summary: This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04972 SPINT2 Knockout cell line (HeLa) Human SPINT2 1:3~1:6 Negative Online Inquiry
KO04973 SPINT2 Knockout cell line (HCT 116) Human SPINT2 1:2~1:4 Negative Online Inquiry
KO04974 SPINT2 Knockout cell line (HEK293) Human SPINT2 1:3~1:6 Negative Online Inquiry
KO04975 SPINT2 Knockout cell line (A549) Human SPINT2 1:3~1:4 Negative Online Inquiry

Background

SPINT2 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the SPINT2 gene's function in various biological processes. Through targeted genome editing techniques, such as CRISPR/Cas9, these cell lines have been crafted to lack the functional SPINT2 gene. As a result, researchers can investigate the biological implications of SPINT2 loss in cellular signaling pathways, tumorigenesis, and developmental biology.

The primary function of SPINT2 is as a serine protease inhibitor, which regulates several physiological processes by modulating extracellular matrix remodeling and cell signaling. By utilizing these knockout cell lines, scientists can elucidate the mechanisms by which SPINT2 influences cell behavior and interactions, offering insights into its role in diseases such as cancer and fibrosis. The knockdown of SPINT2 can help in assessing its contributions to pathways such as TGF-beta signaling, which is critical in many pathological conditions.

The scientific importance of SPINT2 Gene Knockout Cell Lines lies in their applications across diverse research fields, including cancer biology, immunology, and regenerative medicine. The ability to observe the direct effects of SPINT2 deletion allows for the identification of novel therapeutic targets and the development of innovative strategies tailored to the manipulation of related pathways.

Compared to traditional wild-type cell lines, these knockout models provide unique advantages in precision and specificity, allowing researchers to achieve clearer, more reliable results without confounding data from functional SPINT2 activity. In addition, our SPINT2 knockouts are validated for consistent performance across multiple experiments, ensuring reproducibility.

For researchers and clinicians focused on elucidating the genetic underpinnings of diseases or exploring therapeutic interventions, the SPINT2 Gene Knockout Cell Lines are invaluable tools. They enable a deeper understanding of the molecular mechanisms at play and support the translation of research findings into potential clinical applications.

As a leader in the field of cell line development and genetic engineering, our company prides itself on delivering high-quality products, backed by rigorous scientific validation and expertise. We are committed to empowering your research with innovative solutions that advance the frontiers of biomedical science.

Please note that all services are for research use only. Not intended for any clinical use.

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