Gene: SPAG4
Official Full Name: sperm associated antigen 4provided by HGNC
Gene Summary: The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35277 | SPAG4 Knockout cell line (HeLa) | Human | SPAG4 | 1:3~1:6 | Negative | Online Inquiry |
KO35278 | SPAG4 Knockout cell line (HCT 116) | Human | SPAG4 | 1:2~1:4 | Negative | Online Inquiry |
KO35279 | SPAG4 Knockout cell line (A549) | Human | SPAG4 | 1:3~1:4 | Negative | Online Inquiry |
SPAG4 Gene Knockout Cell Lines are specially engineered cellular models designed to investigate the specific functions and pathways involved in male fertility, particularly those associated with motility and other sperm-related processes. These cell lines have undergone targeted gene editing to disrupt the SPAG4 gene, which is essential for the structural integrity and functionality of sperm flagella, thereby allowing researchers to study the downstream effects of this gene's absence in controlled environments.
The primary mechanism by which SPAG4 Gene Knockout Cell Lines operate involves the cessation of functional protein synthesis associated with the SPAG4 gene. Without this crucial component, researchers can observe critical phenotypical changes that mimic conditions of infertility, providing insights into the underlying molecular mechanisms. Furthermore, these cell lines serve as valuable tools for testing the efficacy of potential therapeutic interventions aimed at reversing or mitigating spermatogenic defects.
The scientific importance of these cell lines is underscored by their application in both research and clinical settings. They facilitate investigations into genetic mutations leading to infertility, enabling the identification of novel biomarkers and therapeutic targets. Due to the significant public health implications of male infertility, SPAG4 Gene Knockout Cell Lines are particularly valuable for pharmaceutical companies and academic research institutions focused on reproductive health.
In comparison to other knockout models, SPAG4 Gene Knockout Cell Lines provide a highly specific and relevant system for studying male reproduction. These cell lines are rigorously validated to ensure reproducibility and reliability, giving them a competitive edge over alternative models that may yield inconsistent results.
For researchers and clinicians, the potential insights gained from using SPAG4 Gene Knockout Cell Lines can not only enhance understanding of male fertility but also promote the development of targeted therapies for infertility issues. Our commitment to delivering high-quality biological products is reflected in our extensive expertise in gene editing technologies, ensuring that you receive top-tier resources for your scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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