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SP6 Knockout Cell Lines

Gene: SP6

Official Full Name: Sp6 transcription factorprovided by HGNC

Gene Summary: SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26019 SP6 Knockout cell line (HeLa) Human SP6 1:3~1:6 Negative Online Inquiry
KO26020 SP6 Knockout cell line (HCT 116) Human SP6 1:2~1:4 Negative Online Inquiry
KO26021 SP6 Knockout cell line (HEK293) Human SP6 1:3~1:6 Negative Online Inquiry
KO26022 SP6 Knockout cell line (A549) Human SP6 1:3~1:4 Negative Online Inquiry

Background

SP6 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to disrupt the expression of specific target genes, facilitating in-depth functional studies of gene function and regulation. Utilizing the advanced CRISPR-Cas9 technology, these cell lines provide a powerful platform for researchers to investigate the role of individual genes in cellular processes, disease states, and therapeutic responses.

The key mechanism behind the functionality of SP6 Gene Knockout Cell Lines lies in their precision gene editing capabilities. By targeting specific sequences within the genome, the CRISPR system introduces double-strand breaks, leading to error-prone repair mechanisms that result in frameshifts or deletions. This results in a complete loss of gene function, thereby permitting the elucidation of gene interactions and the study of phenotypic outcomes resulting from gene inactivation.

The scientific importance of SP6 Gene Knockout Cell Lines cannot be overstated. In research settings, they serve as invaluable tools for the dissection of signaling pathways, exploration of genetic interactions, and development of disease models, contributing significantly to our understanding of cellular mechanisms. Clinically, these cell lines pave the way for novel therapeutic strategies by identifying potential drug targets and elucidating resistance mechanisms in various diseases, including cancer and genetic disorders.

Compared to traditional gene knockout methods, the SP6 Gene Knockout Cell Lines offer unparalleled specificity and efficiency. They provide consistent, reliable results and reduce variability that is often seen with other approaches. Additionally, these cell lines are available in multiple backgrounds, tailored for diverse experimental setups, thereby enhancing their utility across different research disciplines.

For researchers and clinicians alike, the SP6 Gene Knockout Cell Lines deliver a significant advantage in both speed and accuracy, facilitating groundbreaking discoveries that advance our understanding of biology and enhance therapeutic innovation. With a commitment to cutting-edge technology and a portfolio of biologically relevant products, our company positions itself at the forefront of genomic research, ensuring that our offerings meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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