Home / SP3 Knockout Cell Lines

SP3 Knockout Cell Lines

Gene: SP3

Official Full Name: Sp3 transcription factorprovided by HGNC

Gene Summary: This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35292 SP3 Knockout cell line (HeLa) Human SP3 1:3~1:6 Negative Online Inquiry
KO35293 SP3 Knockout cell line (HCT 116) Human SP3 1:2~1:4 Negative Online Inquiry
KO35294 SP3 Knockout cell line (HEK293) Human SP3 1:3~1:6 Negative Online Inquiry
KO35295 SP3 Knockout cell line (A549) Human SP3 1:3~1:4 Negative Online Inquiry

Background

SP3 Gene Knockout Cell Lines are precisely engineered cellular models designed to facilitate the elucidation of gene function and the study of genetic disorders. These cell lines have been developed using cutting-edge CRISPR-Cas9 technology, which enables targeted disruption of the SP3 gene, leading to the absence of its functional protein. This specific knockout facilitates a deeper understanding of the gene's role in critical biological pathways, its interaction with other genes, and implications in various disease states.

The primary mechanism of action involves the precise introduction of double-strand breaks in the target gene, followed by the repair processes of the cell that often result in insertions or deletions, effectively disrupting the gene’s coding sequence. Researchers can observe the phenotypic consequences of SP3 deficiency, providing insights into its involvement in cellular processes such as transcription regulation, apoptosis, and tumorigenesis.

Scientifically, SP3 Gene Knockout Cell Lines are invaluable in both research and clinical contexts. They offer a robust platform for drug discovery, functional genomics, and the modeling of genetic diseases. By using these cell lines, researchers can explore therapeutic targets and evaluate the potential efficacy of new treatments in conditions where SP3 has been implicated.

What sets SP3 Gene Knockout Cell Lines apart from alternative products is their superior specificity and reliability, stemming from our proprietary engineering protocols that ensure minimal off-target effects. Additionally, these cell lines are rigorously validated for consistent performance across multiple experiments, significantly reducing time and variability in research outcomes.

For researchers and clinicians focused on gene function and pathology, the availability of SP3 Gene Knockout Cell Lines represents an essential resource, enriching studies that can lead to groundbreaking discoveries and innovative therapeutic strategies. Building on years of expertise in cellular biology and gene editing, our company is committed to delivering high-quality biological products tailored to meet the demanding needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.