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SORT1 Knockout Cell Lines

Gene: SORT1

Official Full Name: sortilin 1provided by HGNC

Gene Summary: This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00510 SORT1 Knockout cell line (HEK293) Human SORT1 1:3~1:6 Negative Online Inquiry
KO05791 SORT1 Knockout cell line (HeLa) Human SORT1 1:3~1:6 Negative Online Inquiry
KO05792 SORT1 Knockout cell line (HCT 116) Human SORT1 1:2~1:4 Negative Online Inquiry
KO05793 SORT1 Knockout cell line (A549) Human SORT1 1:3~1:4 Negative Online Inquiry

Background

SORT1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the SORT1 gene, which is crucial for the intracellular trafficking of various proteins, including neurotrophic factors and certain receptor proteins. These knockout cell lines enable researchers to study the functional implications of SORT1 deficiency, elucidating its role in neurodegenerative diseases and metabolic disorders. The mechanisms underlying SORT1 perturbations often involve altered cellular signaling and transport pathways, making these models invaluable for dissecting the biological processes impacted by this specific genetic modification.

The scientific importance of SORT1 Gene Knockout Cell Lines lies in their application across fundamental and translational research settings. They provide critical insights into the pathophysiology of conditions such as Alzheimer's disease, cardiovascular diseases, and obesity-related metabolic syndromes. By enabling targeted investigations into the consequences of SORT1 knockout, researchers can generate meaningful data that aid in drug discovery, biomarker identification, and the development of novel therapeutic strategies.

One of the key advantages of utilizing SORT1 Gene Knockout Cell Lines is their specificity and reliability. Unlike alternative methods such as siRNA knockdown or pharmacological inhibition, which may yield heterogeneous results due to off-target effects, these knockout lines offer a stable and robust platform for experimental manipulation. This specificity leads to more reproducible results and enhanced confidence in data interpretation.

Moreover, the availability of these specialized cell lines empowers researchers and clinicians alike to foster innovation and advance studies related to SORT1's biological roles in health and disease. With accurate genetic modifications verified through rigorous screening processes, these cell lines provide an essential resource for the scientific community.

Our company is committed to delivering high-quality, state-of-the-art biological products, and with our expertise in genetic engineering, we offer unparalleled support to researchers seeking to leverage SORT1 Gene Knockout Cell Lines in their work. By choosing our product, users gain access to reliable tools that can significantly enhance their research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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