Gene: SNX5
Official Full Name: sorting nexin 5provided by HGNC
Gene Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00187 | SNX5 Knockout cell line (HCT 116) | Human | SNX5 | 1:2~1:4 | Negative | Online Inquiry |
KO27811 | SNX5 Knockout cell line (HeLa) | Human | SNX5 | 1:3~1:6 | Negative | Online Inquiry |
KO27812 | SNX5 Knockout cell line (HEK293) | Human | SNX5 | 1:3~1:6 | Negative | Online Inquiry |
KO27813 | SNX5 Knockout cell line (A549) | Human | SNX5 | 1:3~1:4 | Negative | Online Inquiry |
SNX5 Gene Knockout Cell Lines are genetically modified cell lines in which the SNX5 gene has been disrupted or "knocked out" using advanced gene editing technologies such as CRISPR-Cas9. The SNX5 gene encodes a sorting nexin protein involved in endosomal trafficking and membrane protein sorting processes. By providing researchers with these specialized cell lines, the product facilitates the exploration of SNX5's physiological roles and its implications in various cellular mechanisms, particularly those related to cellular signaling and membrane dynamics.
The primary function of the SNX5 gene knockout is to enable the assessment of phenotypic changes that result from the absence of SNX5. This is achieved by evaluating alterations in cellular processes such as endocytosis, signal transduction, and intracellular transport. By utilizing these knockout cell lines, researchers can elucidate the contributions of SNX5 to critical biological processes, advancing our understanding of conditions like cancer, neurodegeneration, and metabolic disorders where SNX5 may play a pathogenic role.
In research and clinical settings, the SNX5 Gene Knockout Cell Lines are invaluable tools for gaining insights into the molecular mechanisms underpinning health and disease. Their use can lead to the identification of novel therapeutic targets and biomarkers, contributing to the development of innovative treatment strategies. Compared to traditional cell lines, the knockout models provide specific advantages, including the ability to study the effects of gene loss in a more controlled environment and the potential to reduce the confounding effects caused by gene redundancy.
For researchers and clinicians aiming to deepen their understanding of endosomal trafficking or related pathways, these knockout cell lines represent a critical asset. They offer the opportunity to conduct experiments that can reveal fundamental insights into cellular biology and therapeutic interventions.
Our company prides itself on its expertise in producing high-quality, genetically modified cell lines, ensuring that our products meet rigorous scientific standards. With our commitment to supporting innovative research, the SNX5 Gene Knockout Cell Lines stand as a testament to our dedication to empowering the scientific community with advanced tools for discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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