Gene: SNPH
Official Full Name: syntaphilinprovided by HGNC
Gene Summary: Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32817 | SNPH Knockout cell line (HCT 116) | Human | SNPH | 1:2~1:4 | Negative | Online Inquiry |
KO32818 | SNPH Knockout cell line (HEK293) | Human | SNPH | 1:3~1:6 | Negative | Online Inquiry |
KO32819 | SNPH Knockout cell line (A549) | Human | SNPH | 1:3~1:4 | Negative | Online Inquiry |
SNPH Gene Knockout Cell Lines represent a pivotal advancement in genetic research, engineered to facilitate the study of the physiological and pathological roles of the synaptopodin (SNPH) gene. By employing CRISPR/Cas9 genome editing technology, these cell lines have been meticulously crafted to induce targeted disruptions of the SNPH gene, thereby providing researchers with an invaluable tool to investigate gene function and its implications in various biological processes.
The primary mechanism of action involves the precise deletion or modification of the SNPH gene, leading to the absence of synaptopodin protein expression. This disruption allows for extensive examination of downstream effects on cellular signaling pathways, synaptic integrity, and overall cellular function. Researchers can utilize these knockout models to explore the gene's involvement in neurodevelopmental disorders, neurodegenerative diseases, and other conditions where synaptic health is crucial.
The scientific importance of SNPH Gene Knockout Cell Lines extends into both basic and applied research, serving as a cornerstone for drug discovery, disease modeling, and therapeutic development. In clinical settings, understanding the role of SNPH in neuron function can unveil potential therapeutic targets for conditions related to synaptic dysfunction, making these cell lines essential for translational research.
Distinct from alternative models, our SNPH Gene Knockout Cell Lines are validated for high specificity and efficiency, ensuring robust research outputs. They offer a reliable and reproducible platform, critical for obtaining consistent results across experiments. Additionally, our cell lines are readily available and come with comprehensive support, empowering researchers to expedite their studies with confidence.
In conclusion, SNPH Gene Knockout Cell Lines are a vital resource for researchers and clinicians aiming to explore the complexities of synaptic biology and its implications for health and disease. Backed by our company’s expertise in cellular biology and genomic engineering, we are committed to providing high-quality biological products that enrich the scientific community and pave the way for groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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