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SMG7 Knockout Cell Lines

Gene: SMG7

Official Full Name: SMG7 nonsense mediated mRNA decay factorprovided by HGNC

Gene Summary: This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32576 SMG7 Knockout cell line (HeLa) Human SMG7 1:3~1:6 Negative Online Inquiry
KO32577 SMG7 Knockout cell line (HCT 116) Human SMG7 1:2~1:4 Negative Online Inquiry
KO32578 SMG7 Knockout cell line (HEK293) Human SMG7 1:3~1:6 Negative Online Inquiry

Background

SMG7 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to remove or "knock out" the SMG7 gene, an essential component in the mechanisms of mRNA surveillance and decay. This innovative product serves as a powerful tool for researchers to study gene function, cellular processes, and disease mechanisms related to aberrant mRNA regulation. The key function of these knockout cell lines lies in their ability to provide a controlled environment in which the effects of the absence of SMG7 can be analyzed, facilitating insights into the gene's role in diverse biological pathways.

The SMG7 gene is crucial for the decay of aberrant mRNAs and regulation of gene expression, making the SMG7 knockout cell lines pivotal for understanding various cellular stress responses and their implications in diseases such as cancer and neurodegenerative disorders. By using these cell lines, researchers can observe the consequences of disrupted mRNA surveillance, leading to potential breakthroughs in therapeutic targeting and biomarker discovery.

One of the major advantages of SMG7 Gene Knockout Cell Lines is their reproducibility and specificity, allowing for consistent results across experiments. This product stands out from traditional methods of gene silencing, such as RNA interference, by providing a stable genetic alteration rather than temporary suppression. Consequently, researchers can conduct long-term studies without variability introduced by transient expression changes.

For both researchers and clinicians, SMG7 Gene Knockout Cell Lines offer invaluable insights into gene functionality and the molecular basis of diseases. The ability to elucidate the role of SMG7 can guide the development of novel therapeutic approaches and strategies in personalized medicine.

Our company prides itself on delivering high-quality biological products supported by extensive expertise in genetic engineering and cell line development. By providing precise and reliable tools like the SMG7 Gene Knockout Cell Lines, we empower scientific exploration and discovery that can lead to impactful health advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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