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SMARCC2 Knockout Cell Lines

Gene: SMARCC2

Official Full Name: SWI/SNF related BAF chromatin remodeling complex subunit C2provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35338 SMARCC2 Knockout cell line (HeLa) Human SMARCC2 1:3~1:6 Negative Online Inquiry
KO35339 SMARCC2 Knockout cell line (HCT 116) Human SMARCC2 1:2~1:4 Negative Online Inquiry
KO35340 SMARCC2 Knockout cell line (HEK293) Human SMARCC2 1:3~1:6 Negative Online Inquiry
KO35341 SMARCC2 Knockout cell line (A549) Human SMARCC2 1:3~1:4 Negative Online Inquiry

Background

SMARCC2 Gene Knockout Cell Lines represent a sophisticated tool in genetic research, designed to facilitate the study of the SMARCC2 gene, known for its involvement in chromatin remodeling and gene regulation. These engineered cell lines have been meticulously developed using CRISPR/Cas9 technology to ensure the precise ablation of the SMARCC2 gene, thereby providing a comprehensive platform for exploring its functional implications in various biological processes.

The primary function of the SMARCC2 Gene Knockout Cell Lines is to serve as a model system for understanding the gene's role in cellular processes such as proliferation, differentiation, and response to external stimuli. By observing the phenotypic changes that occur following gene knockout, researchers can elucidate the molecular pathways affected by the absence of SMARCC2. The mechanism of action relies on the targeting of the SMARCC2 sequence, leading to the disruption of its coding region, and offering a direct approach to study its contributions to oncogenesis, development, and other vital cellular mechanisms.

From a scientific perspective, these cell lines are invaluable in both research and clinical settings. Their utility spans across cancer biology, developmental biology, and therapeutic target identification. They provide an essential resource for researchers aiming to investigate the impact of SMARCC2 loss on tumorigenesis, making them crucial for developing targeted therapies and personalized medicine approaches.

One significant advantage of the SMARCC2 Gene Knockout Cell Lines over traditional methods—such as siRNA knockdown—is their enduring ability to maintain stable gene disruption. This stability not only permits long-term studies but also eliminates the variability often observed in transient knockdown approaches. Furthermore, these cell lines come with full documentation of characterization and validation, providing confidence in experimental reproducibility.

Researchers and clinicians will find immense value in integrating SMARCC2 Gene Knockout Cell Lines into their studies due to their precise gene targeting, long-term stability, and the potential to generate reproducible results that can aid in groundbreaking discoveries.

Our company, a leader in biotechnological innovation, is committed to delivering high-quality biological products that empower scientists in their quest to advance knowledge in molecular biology and medicine. With a team of experienced researchers and a robust platform for genetic editing, we ensure that our offerings not only meet but exceed the expectations of our users.

Please note that all services are for research use only. Not intended for any clinical use.

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