Gene: SLC9B2
Official Full Name: solute carrier family 9 member B2provided by HGNC
Gene Summary: Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00923 | SLC9B2 Knockout cell line(HEK293) | Human | SLC9B2 | 1:3~1:6 | Negative | Online Inquiry |
KO00924 | SLC9B2 Knockout cell line(HeLa) | Human | SLC9B2 | 1:3~1:6 | Negative | Online Inquiry |
KO14097 | SLC9B2 Knockout cell line (HCT 116) | Human | SLC9B2 | 1:2~1:4 | Negative | Online Inquiry |
KO14098 | SLC9B2 Knockout cell line (A549) | Human | SLC9B2 | 1:3~1:4 | Negative | Online Inquiry |
SLC9B2 Gene Knockout Cell Lines are specialized cellular models engineered to selectively disrupt the SLC9B2 gene, which encodes a sodium/hydrogen exchanger involved in pH regulation and ion transport across cellular membranes. These knockout cell lines serve as invaluable tools for elucidating the physiological functions and biochemical pathways associated with SLC9B2 in various biological contexts.
The primary mechanism of action involves the complete removal of the SLC9B2 gene from the cell's genomic DNA. This knockout allows researchers to study the downstream effects of SLC9B2 deficiency, particularly regarding cellular homeostasis, signaling pathways, and responses to pharmacological agents. By providing a platform for loss-of-function studies, these cell lines empower scientists to unravel the intricacies of sodium and hydrogen ion transport, which are essential in understanding numerous cellular processes.
The scientific importance of SLC9B2 Gene Knockout Cell Lines cannot be overstated, particularly in research focused on cardiovascular health, neurobiology, and metabolic disorders. Given that SLC9B2 has been implicated in various pathologies, including heart disease and kidney dysfunction, these cell lines offer critical insights that can facilitate the discovery of novel therapeutic targets.
What sets our SLC9B2 Gene Knockout Cell Lines apart from alternatives is their high fidelity in gene editing and extensive characterization. Each line is rigorously validated to ensure specific knockout efficiency and cellular viability, providing researchers with reliable and reproducible experimental models. Additionally, our product comes with comprehensive technical support and accompanying data to assist researchers in optimizing their experiments, significantly enhancing the overall user experience.
For researchers and clinicians, these knockout cell lines are indispensable for probing the complexities of ion transport mechanisms, screening potential drug candidates, and developing innovative treatment strategies. Our commitment to excellence is reflected in our state-of-the-art gene editing technologies and a dedicated team of experts who continually strive to provide high-quality biological research tools, ensuring that your research goals are met with precision and reliability.
Please note that all services are for research use only. Not intended for any clinical use.
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