Gene: SLC9A7
Official Full Name: solute carrier family 9 member A7provided by HGNC
Gene Summary: This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24728 | SLC9A7 Knockout cell line (HeLa) | Human | SLC9A7 | 1:3~1:6 | Negative | Online Inquiry |
KO24729 | SLC9A7 Knockout cell line (HCT 116) | Human | SLC9A7 | 1:2~1:4 | Negative | Online Inquiry |
KO24730 | SLC9A7 Knockout cell line (HEK293) | Human | SLC9A7 | 1:3~1:6 | Negative | Online Inquiry |
KO24731 | SLC9A7 Knockout cell line (A549) | Human | SLC9A7 | 1:3~1:4 | Negative | Online Inquiry |
SLC9A7 Gene Knockout Cell Lines are specially engineered cellular models that have had the SLC9A7 gene, known for encoding a sodium/hydrogen exchanger, systematically disrupted. This product serves as a critical tool for researchers investigating the physiological and pathological roles of SLC9A7 in various cellular processes, particularly in endosomal and lysosomal functions. By knocking out this gene, researchers can observe the resultant cellular phenotypes and elucidate the biological pathways that involve this membrane transport protein.
The primary function of SLC9A7 involves maintaining cellular ion homeostasis and pH regulation in endosomes, which is crucial for processes such as nutrient uptake, signal transduction, and membrane trafficking. The SLC9A7 knockout cell lines allow for a deeper exploration into the disruptions in these mechanisms and their association with various diseases, including neurodegenerative disorders and cancer. By utilizing these knockout cell lines, scientists can perform functional assays to assess changes in cellular behavior, such as altered vesicle trafficking, which contributes to the understanding of cellular dysfunction in disease states.
Scientifically, these cell lines are invaluable in research settings as they provide a reliable, reproducible way to study gene function without the confounding effects of the endogenous SLC9A7 gene, thereby enhancing experimental precision. Compared to other knockout models, the SLC9A7 Gene Knockout Cell Lines are optimized for easy handling and robust performance in high-throughput screening applications, making them a superior choice for laboratories looking to conduct extensive biochemical and genetic analyses.
Researchers and clinicians will find significant value in these knockout cell lines, as they not only facilitate studies aimed at unraveling the complexities of cellular ion regulation but also pave the way for novel therapeutic strategies targeting diseases linked to aberrant SLC9A7 function. With our commitment to excellence in biological products, our company stands at the forefront of providing advanced scientific solutions, ensuring that you have access to cutting-edge research tools that can drive your investigations forward.
Please note that all services are for research use only. Not intended for any clinical use.
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