Gene: SLC39A3
Official Full Name: solute carrier family 39 member 3provided by HGNC
Gene Summary: Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Predicted to act upstream of or within several processes, including T cell homeostasis; chordate embryonic development; and zinc ion transport. Predicted to be located in hippocampal mossy fiber to CA3 synapse. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26865 | SLC39A3 Knockout cell line (HeLa) | Human | SLC39A3 | 1:3~1:6 | Negative | Online Inquiry |
KO26866 | SLC39A3 Knockout cell line (HCT 116) | Human | SLC39A3 | 1:2~1:4 | Negative | Online Inquiry |
KO26867 | SLC39A3 Knockout cell line (HEK293) | Human | SLC39A3 | 1:3~1:6 | Negative | Online Inquiry |
KO26868 | SLC39A3 Knockout cell line (A549) | Human | SLC39A3 | 1:3~1:4 | Negative | Online Inquiry |
SLC39A3 Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the SLC39A3 gene, which encodes a zinc transporter responsible for cellular zinc homeostasis. By employing CRISPR-Cas9 gene editing technology, these knockout cell lines provide researchers with a powerful tool to investigate the role of zinc transport in various physiological and pathological contexts. Zinc is an essential trace element that plays crucial roles in cellular growth, differentiation, and signaling, making the SLC39A3 gene a significant contributor to studies on diseases such as cancer, diabetes, and neurodegeneration.
The primary function of SLC39A3 involves the regulation of zinc influx into cells, influencing enzymatic activities and cellular signaling pathways. By creating knockout models, researchers can observe the downstream effects of impaired zinc transport, offering insights into how dysregulated zinc homeostasis can lead to disease progression. These cell lines are invaluable in in vitro studies, facilitating the exploration of cellular responses under conditions of zinc deficiency or overload.
The scientific importance of SLC39A3 Gene Knockout Cell Lines extends to translational research and drug development. These models are particularly useful for screening potential therapeutic agents that target zinc-related pathways, enabling the identification of new interventions for conditions tied to zinc dysregulation.
Unique advantages of SLC39A3 knockout cell lines include their versatility across different cell types and their customization options, allowing for the exploration of various signaling pathways influenced by zinc. Unlike traditional knockout approaches, our state-of-the-art genetic engineering guarantees high specificity and efficiency, leading to reproducible and reliable results essential for rigorous scientific inquiry.
For researchers and clinicians delving into molecular biology or therapeutic development, the value of SLC39A3 Gene Knockout Cell Lines lies in their ability to elucidate complex biological mechanisms and potential treatment modalities. Our company is committed to advancing research capabilities with cutting-edge biological products, backed by comprehensive expertise in genetic engineering and cell line development, ensuring that our offerings meet the highest standards of quality and reliability.
Please note that all services are for research use only. Not intended for any clinical use.
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