Gene: SLC25A5
Official Full Name: solute carrier family 25 member 5provided by HGNC
Gene Summary: This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00667 | SLC25A5 gRNA3-gRNA4 KO plasmid | SLC25A5 | $850 | |||
GP00668 | SLC25A5 gRNA1-gRNA2 KO plasmid | SLC25A5 | $850 | |||
KO00847 | SLC25A5 Knockout cell line(KYSE-150) | Human | SLC25A5 | 1:2~1:4 | Negative | Online Inquiry |
KO07998 | SLC25A5 Knockout cell line (HeLa) | Human | SLC25A5 | 1:3~1:6 | Negative | Online Inquiry |
KO07999 | SLC25A5 Knockout cell line (HCT 116) | Human | SLC25A5 | 1:2~1:4 | Negative | Online Inquiry |
KO08000 | SLC25A5 Knockout cell line (HEK293) | Human | SLC25A5 | 1:3~1:6 | Negative | Online Inquiry |
KO08001 | SLC25A5 Knockout cell line (A549) | Human | SLC25A5 | 1:3~1:4 | Negative | Online Inquiry |
SLC25A5 Gene Knockout Cell Lines represent a cutting-edge tool in the field of molecular biology, specifically designed to facilitate the study of mitochondrial functions and energy metabolism. The SLC25A5 gene encodes the adenosine triphosphate (ATP) transport protein, which plays a critical role in the export of ATP from mitochondria to the cytoplasm, thereby influencing various cellular processes including energy homeostasis and apoptosis. By using CRISPR/Cas9 gene-editing technology, these cell lines have been expertly engineered to eliminate the expression of the SLC25A5 gene, allowing researchers to observe the resultant effects on mitochondrial ATP levels, cellular respiration, and overall metabolic pathways.
The key function of these knockout cell lines lies in their ability to serve as a platform for dissecting the cellular mechanisms underlying mitochondrial dysfunctions and their implications in diseases like cancer, metabolic syndromes, and neurodegenerative disorders. This utility enables researchers to delve deeper into understanding how altered ATP homeostasis can affect cell signaling, growth, and viability. Moreover, the SLC25A5 knockout models facilitate advanced drug discovery efforts by providing insight into how potential therapeutics may target mitochondrial functions.
One of the primary advantages of using SLC25A5 Gene Knockout Cell Lines over traditional methods is their specificity and efficiency in gene disruption. Unlike conventional siRNA approaches that may lead to transient effects or off-target effects, these knockout lines provide a stable genetic alteration, resulting in consistent and reproducible results. This stability enhances experimental reliability and the interpretability of data, which is crucial for driving significant advancements in both basic and applied research.
For researchers and clinicians focusing on metabolic disorders, cancer, or mitochondrial diseases, these cell lines are invaluable tools that accelerate the pace of discovery by allowing for high-throughput screenings and functional assays. Furthermore, the biological relevance of these models makes them ideal for translating findings into therapeutic strategies.
Our company prides itself on the development of high-quality genetic products, supported by extensive expertise in molecular biology and advanced gene-editing techniques. With a commitment to innovation and excellence, our SLC25A5 Gene Knockout Cell Lines equip scientists with the resources needed to push the boundaries of research and contribute meaningfully to the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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