Gene: SLC25A12
Official Full Name: solute carrier family 25 member 12provided by HGNC
Gene Summary: This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34019 | SLC25A12 Knockout cell line (HeLa) | Human | SLC25A12 | 1:3~1:6 | Negative | Online Inquiry |
KO34020 | SLC25A12 Knockout cell line (HCT 116) | Human | SLC25A12 | 1:2~1:4 | Negative | Online Inquiry |
KO34021 | SLC25A12 Knockout cell line (HEK293) | Human | SLC25A12 | 1:3~1:6 | Negative | Online Inquiry |
KO34022 | SLC25A12 Knockout cell line (A549) | Human | SLC25A12 | 1:3~1:4 | Negative | Online Inquiry |
SLC25A12 Gene Knockout Cell Lines represent a revolutionary tool in the field of molecular biology, specifically designed to facilitate in-depth studies of the SLC25A12 gene's role in cellular metabolism and disease pathology. SLC25A12 encodes a mitochondrial transporter that is critical for the transport of aspartate and glutamate across the mitochondrial membrane, influencing various metabolic pathways. By employing CRISPR-Cas9 gene editing technology, these knockout cell lines have successfully disrupted the expression of the SLC25A12 gene, allowing researchers to observe the resultant phenotypic and molecular changes.
The main function of SLC25A12 Gene Knockout Cell Lines lies in their ability to elucidate the impact of SLC25A12 on cellular physiology. Researchers can utilize these models to study metabolic disorders, neurodegeneration, and other pathologies associated with dysfunctional mitochondrial transport mechanisms. The knockout cell lines serve as valuable experimental frameworks for assessing mitochondrial function, exploring metabolic flux, and investigating potential therapeutic targets.
This product’s scientific significance transcends basic research; it is poised to have substantial implications in translational medicine. The unique ability to study the direct consequences of SLC25A12 disruption provides insights into both cancer biology and neurodevelopmental conditions, making this product indispensable for both academic and clinical researchers.
Compared to other available models, SLC25A12 Gene Knockout Cell Lines offer advantages such as precise gene editing without random integration, ensuring validity and reproducibility of results. Additionally, these cell lines are readily adaptable for high-throughput screening and personalized medicine applications, catering to the diverse needs of modern research.
In a rapidly evolving biomedical landscape, the availability of robust, well-characterized knockout models such as these is invaluable to researchers and clinicians alike, facilitating the discovery and development of novel therapeutic interventions. Backed by years of expertise in genetic engineering and cell line development, our company is committed to providing high-quality biological products that empower scientific inquiry and drive forward the frontiers of medical research.
Please note that all services are for research use only. Not intended for any clinical use.
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