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SLC15A2 Knockout Cell Lines

Gene: SLC15A2

Official Full Name: solute carrier family 15 member 2provided by HGNC

Gene Summary: The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35371 SLC15A2 Knockout cell line (HCT 116) Human SLC15A2 1:2~1:4 Negative Online Inquiry

Background

SLC15A2 Gene Knockout Cell Lines are genetically modified cell lines in which the SLC15A2 gene, responsible for the transport of peptides and certain drugs across cellular membranes, has been systematically disrupted. By creating these knockout models, researchers can investigate the physiological roles of SLC15A2 and assess its implications in various biological processes, including immune response, drug metabolism, and disease pathogenesis.

The primary function of SLC15A2 involves mediating the uptake of di- and tripeptides, as well as facilitating the transport of certain therapeutic agents. The knockout of this gene allows scientists to examine changes in cellular behavior when peptide transport is impaired. This includes alterations in amino acid profiles, nutrient uptake, and responses to pharmacological compounds, enabling deeper insights into the mechanisms governing drug efficacy and toxicity.

In both research and clinical settings, SLC15A2 Gene Knockout Cell Lines have become invaluable tools for studying drug interactions and metabolic disorders, specifically those related to peptide absorption and immune modulation. Their use in preclinical models can significantly enhance the understanding of diseases such as inflammatory bowel disease and certain types of cancer, where aberrant nutrient uptake may play a role.

One of the critical advantages of these knockout cell lines is their ability to provide a clear and specific model for investigating gene function in a controlled environment. Unlike other gene editing techniques or methods, SLC15A2 knockout lines facilitate reproducible effects, making results more reliable and easier to interpret. Additionally, these cell lines are designed for ease of use and can be readily integrated into existing laboratory workflows, minimizing disruption for researchers.

For investigators focused on drug development, clinical pharmacology, or translational medicine, the SLC15A2 Gene Knockout Cell Lines offer a robust platform for uncovering novel therapeutic targets and understanding complex interactions within the body. By utilizing our product, researchers can harness the power of genetic modification to drive meaningful discoveries in their fields.

Our company, with its extensive experience in genetic engineering and cell line development, is dedicated to providing high-quality biological products. We are committed to supporting your research endeavors with trustworthy, precise, and effective tools like the SLC15A2 Gene Knockout Cell Lines, designed to propel your work forward in the ever-evolving landscape of biological science.

Please note that all services are for research use only. Not intended for any clinical use.

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