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SKIL Knockout Cell Lines

Gene: SKIL

Official Full Name: SKI like proto-oncogeneprovided by HGNC

Gene Summary: The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35418 SKIL Knockout cell line (HeLa) Human SKIL 1:3~1:6 Negative Online Inquiry
KO35419 SKIL Knockout cell line (HCT 116) Human SKIL 1:2~1:4 Negative Online Inquiry
KO35420 SKIL Knockout cell line (HEK293) Human SKIL 1:3~1:6 Negative Online Inquiry
KO35421 SKIL Knockout cell line (A549) Human SKIL 1:3~1:4 Negative Online Inquiry

Background

SKIL Gene Knockout Cell Lines are advanced biological tools designed for the precise and efficient study of gene function and regulation in cellular environments. Developed through robust gene editing techniques such as CRISPR-Cas9, these cell lines are engineered to knock out the SKIL gene, allowing researchers to explore its role in various biological processes, including cell signaling, proliferation, and differentiation.

The key function of SKIL Gene Knockout Cell Lines lies in their ability to serve as a model system to simulate the absence of the SKIL gene, providing insights into its biological pathways and interactions. By eliminating this specific gene, researchers can observe resultant phenotypic changes and elucidate the molecular mechanisms at play, paving the way for discoveries related to diseases, developmental biology, and therapeutic interventions.

The scientific importance of these cell lines is profound; they hold the potential to advance our understanding of pathologies where the SKIL gene is implicated, such as cancer and autoimmune disorders. In clinical research settings, they enable the screening of therapeutic candidates, facilitating the development of targeted treatments. Furthermore, these cell lines can be utilized in pharmaceutical applications to assess drug efficacy and safety in a controlled environment.

One of the standout advantages of SKIL Gene Knockout Cell Lines over traditional knockdown methods, such as RNA interference, is their permanence. This stable knockout allows for more reliable data, as the effects of gene loss are consistent over time, mitigating variability from transient transfection approaches. Additionally, these cell lines are rigorously validated for consistency and reproducibility, ensuring that researchers obtain high-quality results.

For researchers and clinicians alike, adopting SKIL Gene Knockout Cell Lines represents a critical step toward uncovering the complexities of gene function and driving innovation in therapeutic strategies. With our commitment to excellence in the development of biological research tools, our company leverages cutting-edge techniques and expertise to deliver products that empower the scientific community to advance discovery and improve healthcare outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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