Gene: SIX1
Official Full Name: SIX homeobox 1provided by HGNC
Gene Summary: The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01474 | SIX1 Knockout cell line(Hep G2) | Human | SIX1 | 1:2~1:4 | Negative | Online Inquiry |
KO14128 | SIX1 Knockout cell line (HeLa) | Human | SIX1 | 1:3~1:6 | Negative | Online Inquiry |
KO14129 | SIX1 Knockout cell line (HCT 116) | Human | SIX1 | 1:2~1:4 | Negative | Online Inquiry |
KO14130 | SIX1 Knockout cell line (HEK293) | Human | SIX1 | 1:3~1:6 | Negative | Online Inquiry |
KO14131 | SIX1 Knockout cell line (A549) | Human | SIX1 | 1:3~1:4 | Negative | Online Inquiry |
SIX1 Gene Knockout Cell Lines are genetically engineered cell lines that specifically have the SIX1 gene disrupted, allowing researchers to study the functions and regulatory mechanisms associated with this essential gene. The SIX1 gene encodes a transcription factor that plays a pivotal role in embryonic development and tissue regeneration, as well as in the progression of various cancers. By employing CRISPR-Cas9 and other gene-editing technologies, these cell lines provide a powerful tool for elucidating the biological pathways influenced by SIX1, thus facilitating a deeper understanding of its implications in both normal physiology and disease states.
The key function of SIX1 Gene Knockout Cell Lines lies in their ability to model the loss-of-function effects of the SIX1 gene. Researchers can utilize these cell lines to investigate how the absence of SIX1 alters cellular behaviors, such as differentiation, proliferation, and apoptosis. Furthermore, these cell lines allow for the evaluation of therapeutic interventions targeting SIX1-related pathways, making them indispensable in cancer research.
From a scientific perspective, the development of SIX1 Gene Knockout Cell Lines has significant importance in both research and clinical applications. These cells are particularly valuable for drug discovery, as they can help identify potential targets and assess the efficacy of novel compounds that modulate SIX1 activity. In clinical settings, understanding the role of SIX1 in tumorigenesis can inform prognostic assessments and treatment strategies for patients with SIX1-associated cancers.
The advantages of using our SIX1 Gene Knockout Cell Lines over alternative models include their high specificity, reproducibility, and the comprehensive data they offer, which can lead to more conclusive research outcomes. Unlike conventional cell lines or transient knockdown strategies that may produce variable results, these knockout cell lines provide a stable and consistent platform for experiments.
For researchers and clinicians seeking to deepen their understanding of SIX1's role in development and disease, our SIX1 Gene Knockout Cell Lines represent an invaluable resource. Our company prides itself on delivering high-quality, rigorously validated biological products that support cutting-edge research and clinical advancements. By choosing our product, you gain access to our extensive expertise in gene editing and molecular biology, empowering your research endeavors with confidence and precision.
Please note that all services are for research use only. Not intended for any clinical use.
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