Gene: SIN3B
Official Full Name: SIN3 transcription regulator family member Bprovided by HGNC
Gene Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in cardiac muscle tissue development; negative regulation of transcription by RNA polymerase II; and skeletal muscle tissue development. Predicted to be located in chromatin and nucleus. Predicted to be part of Sin3-type complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29480 | SIN3B Knockout cell line (HeLa) | Human | SIN3B | 1:3~1:6 | Negative | Online Inquiry |
KO29481 | SIN3B Knockout cell line (HCT 116) | Human | SIN3B | 1:2~1:4 | Negative | Online Inquiry |
KO29482 | SIN3B Knockout cell line (HEK293) | Human | SIN3B | 1:3~1:6 | Negative | Online Inquiry |
KO29483 | SIN3B Knockout cell line (A549) | Human | SIN3B | 1:3~1:4 | Negative | Online Inquiry |
SIN3B Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to have the SIN3B gene completely inactivated. This gene is critical for various biological processes, including transcriptional regulation, cell cycle progression, and apoptosis. By utilizing CRISPR-Cas9 technology, these cell lines facilitate the study of SIN3B's role in cellular behavior and the molecular underpinnings of various diseases, particularly cancer. Researchers can investigate the effects of SIN3B deletion on gene expression, metabolic pathways, and cell signaling, enabling deeper insights into the pathophysiology of disorders linked to aberrant transcriptional control.
The functionality of SIN3B knockouts lies in their ability to emulate physiological conditions that resemble gene dysfunction observed in diseases. When the SIN3B gene is knocked out, there is a noticeable alteration in transcriptional control, which may lead to dysregulation of target genes involved in oncogenesis. The datasets generated from experiments involving these cell lines can contribute significantly to understanding therapy resistance and the developmental pathways of tumor formation and progression.
The scientific importance of SIN3B Gene Knockout Cell Lines is underscored by their wide applicability in both research and clinical settings. They are invaluable tools for drug discovery, particularly in the assessment of novel therapeutics that target transcriptional networks. Additionally, these cell lines can serve as preclinical models to evaluate the efficacy of SIN3B-targeted interventions.
One of the primary advantages of our SIN3B Gene Knockout Cell Lines over alternatives, such as temporary knockdown models, is their stable genetic alteration, which allows for long-term studies and repeatable experiments without variations that temporary methods introduce. This stability ensures reliability in experimental outcomes, making it easier to draw significant conclusions.
For researchers and clinicians, SIN3B Gene Knockout Cell Lines provide a unique opportunity to delve into complex biological mechanisms with accuracy and reproducibility. The insights gained from the use of these models can lead to transformative advancements in therapeutic strategies, particularly in oncology and genetic research.
At [Your Company Name], we pride ourselves on our extensive expertise in developing high-quality biological products, including meticulously engineered cell lines. Our commitment to innovation and scientific integrity ensures that our offerings remain at the forefront of biomedical research, providing researchers with the reliable tools they need to advance their scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.