Gene: SIM2
Official Full Name: SIM bHLH transcription factor 2provided by HGNC
Gene Summary: This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35422 | SIM2 Knockout cell line (HeLa) | Human | SIM2 | 1:3~1:6 | Negative | Online Inquiry |
KO35423 | SIM2 Knockout cell line (HCT 116) | Human | SIM2 | 1:2~1:4 | Negative | Online Inquiry |
KO35424 | SIM2 Knockout cell line (HEK293) | Human | SIM2 | 1:3~1:6 | Negative | Online Inquiry |
KO35425 | SIM2 Knockout cell line (A549) | Human | SIM2 | 1:3~1:4 | Negative | Online Inquiry |
SIM2 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the SIM2 gene and its associated pathways. These cell lines have undergone precision gene editing techniques, such as CRISPR/Cas9, to achieve complete knockout of the SIM2 gene, providing a valuable tool for researchers investigating the gene's biological functions and its role in health and disease.
One of the primary functions of SIM2 Gene Knockout Cell Lines is their ability to elucidate the physiological roles of the SIM2 gene in cellular processes such as differentiation, metabolism, and response to stress. The absence of the SIM2 gene allows researchers to observe changes in gene expression profiles, signaling cascades, and cellular behavior that are indicative of its biological function. This can be particularly significant for studies focusing on developmental biology, cancer research, and neurobiology, as SIM2 is implicated in various developmental pathways and diseases.
The scientific importance of these knockout cell lines extends to numerous research and clinical applications, including drug discovery and developmental studies. Researchers can utilize these cell lines to screen for therapeutic compounds targeting SIM2-related pathways or to better understand the gene’s role in disorders, paving the way for innovative treatment strategies.
Compared to traditional models, such as wild-type cell lines or animal models, SIM2 Gene Knockout Cell Lines offer several advantages. They provide a homogeneous cellular environment, reducing variability, and enabling more consistent results. Additionally, they eliminate the need for complex gene silencing techniques, making them easier to use in a variety of experimental setups.
Researchers, clinicians, and pharma companies will find SIM2 Gene Knockout Cell Lines invaluable in advancing their work. The precise and predictable knockout of the SIM2 gene opens new avenues for breakthroughs in understanding its implications in health and disease, making it a powerful asset for any research laboratory focused on genetic interactions.
Our company is dedicated to delivering high-quality biological products that support cutting-edge research. With expertise in gene editing technologies and a commitment to scientific advancement, we empower researchers with reliable tools like SIM2 Gene Knockout Cell Lines to drive innovation in their fields.
Please note that all services are for research use only. Not intended for any clinical use.
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