Gene: SHROOM2
Official Full Name: shroom family member 2provided by HGNC
Gene Summary: This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38953 | SHROOM2 Knockout cell line (HCT 116) | Human | SHROOM2 | 1:2~1:4 | Negative | Online Inquiry |
KO38954 | SHROOM2 Knockout cell line (HEK293) | Human | SHROOM2 | 1:3~1:6 | Negative | Online Inquiry |
SHROOM2 Gene Knockout Cell Lines are specifically designed cellular models that have undergone targeted gene disruption of the SHROOM2 gene, which is implicated in various cellular processes including cell shape, motility, and tissue morphogenesis. These knockout lines allow researchers to elucidate the molecular pathways involving SHROOM2, providing insights into its role in diseases, particularly those related to neurodevelopment and cancer.
The key function of SHROOM2 Gene Knockout Cell Lines lies in their ability to help scientists investigate the physiological and pathological implications of the SHROOM2 gene absence. By studying these cells, researchers can unravel the mechanisms underlying abnormal cellular behavior and tissue development, particularly in processes such as epithelial-to-mesenchymal transition (EMT) and cytoskeletal remodeling. The disruption of SHROOM2 expression leads to alterations in actin filaments and changes in gene expression profiles, presenting a valuable opportunity for studies on cellular dynamics and signaling pathways.
From a scientific perspective, these knockout cell lines hold great significance for both basic and applied research. They serve as powerful tools for drug discovery and development, allowing researchers to identify potential therapeutic targets in conditions where SHROOM2 is misregulated. Furthermore, their applications extend to translational research where understanding the pathophysiology of diseases at the cellular level is crucial for effective treatment strategies.
Compared to conventional cell lines that express the SHROOM2 gene, our SHROOM2 Gene Knockout Cell Lines provide a unique advantage by eliminating the confounding effects of SHROOM2 activity. This specificity enables a more precise analysis of gene function and interaction, thus streamlining the research process. Additionally, these knockout lines are rigorously validated and characterized, ensuring reliability and reproducibility in experimental designs.
For researchers and clinicians focused on understanding the complex interplay of genes in pathological states, SHROOM2 Gene Knockout Cell Lines represent a valuable asset that enhances experimental rigor and opens new avenues for discovery. Our company specializes in the production of genetically modified cell lines, leveraging cutting-edge gene editing technology to meet the evolving needs of the scientific community. Trust our expertise to provide high-quality models that facilitate breakthrough research in cellular and molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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