Gene: SHFL
Official Full Name: shiftless antiviral inhibitor of ribosomal frameshiftingprovided by HGNC
Gene Summary: This gene is an interferon stimulated gene (ISG) that inhibits viral replication. The encoded protein binds nucleic acids and inhibits programmed -1 ribosomal frameshifting required for translation by many RNA viruses. Viruses inhibited by the protein include Zika virus, dengue virus and the coronaviruses, SARS-CoV and SARS-CoV2. [provided by RefSeq, Aug 2021]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00204 | SHFL Knockout cell line (HeLa) | Human | SHFL | 1:3~1:6 | Negative | Online Inquiry |
KO20835 | SHFL Knockout cell line (HCT 116) | Human | SHFL | 1:2~1:4 | Negative | Online Inquiry |
KO20836 | SHFL Knockout cell line (A549) | Human | SHFL | 1:3~1:4 | Negative | Online Inquiry |
SHFL Gene Knockout Cell Lines are specially designed cellular models that facilitate the study of gene function and characterization of genetic disorders. These lines are created through targeted CRISPR-Cas9 gene editing technology, which allows for precise alterations in the SHFL gene, rendering it non-functional. The resulting knockout cell lines enable researchers to examine the biological role of SHFL in various cellular processes, including differentiation, proliferation, and response to environmental stimuli.
The key function of SHFL Gene Knockout Cell Lines is to elucidate the gene's impact on cellular behavior in a controlled laboratory environment. By systematically disrupting the SHFL gene, researchers can investigate downstream signaling pathways and gene interactions, providing critical insights into its involvement in diseases like cancer and metabolic disorders. This functional analysis is essential for advancing our understanding of genetic contributions to pathology, thus informing potential therapeutic strategies.
Scientifically, the SHFL gene has garnered attention due to its pivotal role in developmental biology and cellular homeostasis. The knockout cell lines are invaluable tools in both basic and translational research, enabling scientists to explore gene-targeted therapies and biomarker discovery. The applications extend into drug development, where understanding the biological ramifications of SHFL disruption can lead to innovative treatment modalities.
Compared to traditional cell lines, SHFL Gene Knockout Cell Lines offer unparalleled specificity and accuracy in gene manipulation without the confounding effects of off-target mutations. Their robustness and reproducibility provide researchers with confidence in experimental outcomes, which is critical for data integrity and scientific validation.
By utilizing SHFL Gene Knockout Cell Lines, researchers and clinicians can significantly propel their investigations into genetic functions and disease mechanisms, making this product an essential asset in any genetics or molecular biology laboratory. Our company boasts extensive expertise in cell line development and genetic engineering, ensuring high-quality products that support cutting-edge research.
Please note that all services are for research use only. Not intended for any clinical use.
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