Gene: SH3GLB2
Official Full Name: SH3 domain containing GRB2 like, endophilin B2provided by HGNC
Gene Summary: Enables identical protein binding activity. Predicted to be involved in membrane organization and postsynaptic neurotransmitter receptor internalization. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14165 | SH3GLB2 Knockout cell line (HeLa) | Human | SH3GLB2 | 1:3~1:6 | Negative | Online Inquiry |
KO14166 | SH3GLB2 Knockout cell line (HCT 116) | Human | SH3GLB2 | 1:2~1:4 | Negative | Online Inquiry |
KO14167 | SH3GLB2 Knockout cell line (HEK293) | Human | SH3GLB2 | 1:3~1:6 | Negative | Online Inquiry |
KO14168 | SH3GLB2 Knockout cell line (A549) | Human | SH3GLB2 | 1:3~1:4 | Negative | Online Inquiry |
SH3GLB2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to elucidate the role of the SH3GLB2 gene in various biological processes. The SH3GLB2 gene encodes a protein involved in the regulation of endocytosis, playing a critical role in cellular signaling and membrane trafficking. Through the CRISPR-Cas9 gene-editing technology, these knockout cell lines exhibit a complete inactivation of the SH3GLB2 gene, allowing researchers to investigate the downstream effects of its absence in a controlled environment.
The primary function of SH3GLB2 involves its interaction with other proteins to facilitate the maturation and recycling of endosomal compartments. With these knockout lines, researchers can observe changes in cellular morphology, signaling pathways, and overall cellular function. This can provide crucial insights into various physiological and pathological processes, including cancer progression, neurodegenerative diseases, and immune responses, thereby establishing SH3GLB2 as a potential therapeutic target.
In research settings, these cell lines are invaluable for functional assays, drug screening, and understanding disease mechanisms. Their precise gene knockout capability allows for a more accurate dissection of biological pathways compared to traditional knockdown methods. Furthermore, the robustness of the CRISPR technology enhances reproducibility in experiments, which is essential for validation and comparative studies.
The SH3GLB2 Gene Knockout Cell Lines offer several advantages over alternatives, including a more reliable gene inactivation and the potential for creating stable cell lines without the confounding variability often associated with transient knockdowns. This will enable a more in-depth exploration of SH3GLB2, making the product particularly appealing to both academic and industrial laboratories focused on innovative research.
By choosing our SH3GLB2 Gene Knockout Cell Lines, researchers are equipped with a powerful tool that stems from our company’s extensive experience in genetic engineering and commitment to providing high-quality biological products. We understand the complexities of cell line development and are dedicated to supporting advancements in research and clinical applications, ensuring that our customers can push the boundaries of scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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