Gene: SH3GL1
Official Full Name: SH3 domain containing GRB2 like 1, endophilin A2provided by HGNC
Gene Summary: This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20588 | SH3GL1 Knockout cell line (HeLa) | Human | SH3GL1 | 1:3~1:6 | Negative | Online Inquiry |
KO20589 | SH3GL1 Knockout cell line (HCT 116) | Human | SH3GL1 | 1:2~1:4 | Negative | Online Inquiry |
KO20590 | SH3GL1 Knockout cell line (HEK293) | Human | SH3GL1 | 1:3~1:6 | Negative | Online Inquiry |
KO20591 | SH3GL1 Knockout cell line (A549) | Human | SH3GL1 | 1:3~1:4 | Negative | Online Inquiry |
The SH3GL1 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered for the targeted disruption of the SH3GL1 gene, which encodes the SH3 domain-containing protein, implicated in various cellular processes, including endocytosis, vesicle trafficking, and the regulation of actin cytoskeleton dynamics. These knockout cell lines serve as invaluable tools for elucidating the physiological roles of SH3GL1 and its downstream signaling pathways.
The primary function of the SH3GL1 Gene Knockout Cell Lines is to facilitate studies aimed at understanding protein interactions, cellular architecture, and the molecular mechanics of diseases related to cellular trafficking disorders. By eliminating the expression of SH3GL1, researchers can assess the resultant phenotypic changes, directly linking this gene to its functionalities and potential pathological implications. The knockout model allows scientists to investigate compensatory pathways and interactions that might arise in the absence of SH3GL1, paving the way for insights into therapeutic targets for conditions such as cancer and neurodegenerative diseases.
Scientific investigations leveraging these cell lines extend to a broad range of applications, from fundamental research exploring gene function to potential clinical translational studies focusing on targeted therapies. The major advantage of SH3GL1 Gene Knockout Cell Lines lies in their specificity and reliability compared to general inhibition techniques like small molecules or RNA interference, which may yield off-target effects or transient results.
The unique selling points include their precise genetic modification, easy integration into existing workflows, and the robust characterization of their cellular behaviors. This product empowers researchers and clinicians alike to delve deeper into the molecular underpinnings of diseases and explore innovative therapeutic avenues.
With a solid foundation in genetic engineering and a commitment to advancing biological research, our company brings expertise and innovation to the forefront of gene-editing technologies. The SH3GL1 Gene Knockout Cell Lines encapsulate our dedication to providing high-quality, relevant, and impactful research tools that facilitate scientific discovery and advancement.
Please note that all services are for research use only. Not intended for any clinical use.
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