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SH3BP4 Knockout Cell Lines

Gene: SH3BP4

Official Full Name: SH3 domain binding protein 4provided by HGNC

Gene Summary: This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01467 SH3BP4 Knockout cell line(HEK293) Human SH3BP4 1:3~1:6 Negative Online Inquiry
KO14173 SH3BP4 Knockout cell line (HeLa) Human SH3BP4 1:3~1:6 Negative Online Inquiry
KO14174 SH3BP4 Knockout cell line (HCT 116) Human SH3BP4 1:2~1:4 Negative Online Inquiry
KO14175 SH3BP4 Knockout cell line (A549) Human SH3BP4 1:3~1:4 Negative Online Inquiry

Background

SH3BP4 Gene Knockout Cell Lines are uniquely engineered cell lines that exhibit the targeted deletion of the SH3BP4 gene, which is crucial in the study of various cellular processes, including vesicle trafficking and signal transduction. These cell lines serve as an invaluable tool for researchers investigating the role of SH3BP4 in both physiological and pathological states, particularly in neurodegenerative disorders and cancers.

The primary function of these knockout cell lines lies in their ability to elucidate the biological roles of SH3BP4 by providing a clear model to study the consequent effects of gene deletion. The absence of SH3BP4 disrupts specific signaling pathways and cellular functions, allowing for a deeper exploration of mechanisms underlying cellular response to stimuli, protein interactions, and pathogen resistance. By employing these cell lines, researchers can perform assays to assess the impact of SH3BP4 on protein dynamics, intracellular trafficking, and the overall cellular environment.

From a scientific perspective, SH3BP4 Gene Knockout Cell Lines have significant implications in both basic research and clinical applications. They offer insights into gene function and regulation, supporting drug discovery and therapeutic strategies aimed at modulating the cellular pathways associated with SH3BP4. Additionally, these models facilitate the study of gene-environment interactions, enabling researchers to explore how external factors might influence SH3BP4-related pathways.

One of the key advantages of utilizing our SH3BP4 Gene Knockout Cell Lines over alternatives, such as transient knockdown methods, lies in their stability and reproducibility. Unlike transient modifications that can yield variable results, our knockout lines provide a consistent platform for longitudinal studies, ensuring that experimental outcomes are both reliable and interpretable. Furthermore, these cell lines are derived from well-established foundational models, ensuring compatibility with a wide variety of experimental protocols.

For researchers and clinicians seeking to advance their understanding of cellular biology or to develop novel therapeutic interventions, these knockout cell lines represent a robust resource. Their engineered specificity enables targeted study, thereby accelerating discovery in areas such as molecular biology, pharmacology, and genetic engineering.

At [Your Company Name], we specialize in providing high-quality biological products tailored to meet the evolving needs of the scientific community. Our expertise guarantees not only the reliability of our SH3BP4 Gene Knockout Cell Lines but also a commitment to supporting groundbreaking research that drives innovation and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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