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SFXN1 Knockout Cell Lines

Gene: SFXN1

Official Full Name: sideroflexin 1provided by HGNC

Gene Summary: Enables L-alanine transmembrane transporter activity and L-serine transmembrane transporter activity. Involved in L-alanine transport; L-serine transport; and serine import into mitochondrion. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01586 SFXN1 Knockout cell line (HeLa) Human SFXN1 1:3~1:6 Negative Online Inquiry
KO01587 SFXN1 Knockout cell line (HCT 116) Human SFXN1 1:2~1:4 Negative Online Inquiry
KO01588 SFXN1 Knockout cell line (HEK293) Human SFXN1 1:3~1:6 Negative Online Inquiry
KO01589 SFXN1 Knockout cell line (A549) Human SFXN1 1:3~1:4 Negative Online Inquiry

Background

SFXN1 Gene Knockout Cell Lines are genetically engineered cell models designed to specifically disable the SFXN1 gene, which encodes a protein implicated in various biological processes, including mitochondrial function and metabolism. By completely knocking out this gene, these cell lines allow researchers to study the resultant phenotypic changes, elucidating the role of SFXN1 in cellular homeostasis, energy production, and response to stress.

The key mechanism employed in creating these knockout cell lines involves the use of CRISPR-Cas9 technology, which facilitates precise gene editing by introducing double-strand breaks at the target gene locus. Once the SFXN1 gene is disrupted, subsequent cellular assays can measure impacts on mitochondrial function, oxidative stress response, and metabolic profiling, allowing for nuanced understanding of the gene's biological significance.

In research settings, SFXN1 knockout cell lines are critical for investigating underlying mechanisms related to various disease states, including metabolic disorders and neurodegeneration, thereby advancing biomedical research. Clinically, they provide a platform for drug screening and therapeutic development, particularly in identifying compounds that can modulate the functional consequences of SFXN1 deletion.

What sets SFXN1 Knockout Cell Lines apart from alternatives is their specificity and precision; unlike conventional methods that may yield partial knockdowns or introduce off-target effects, these cell lines offer a reliable, reproducible model for effective exploration of SFXN1's role. Furthermore, the ability to easily culture and manipulate these cells enhances their appeal to researchers looking for efficient experimental designs.

Our commitment to delivering high-quality biological products is backed by years of expertise in genetic engineering and cell line development. By utilizing SFXN1 Gene Knockout Cell Lines, researchers and clinicians can significantly elevate their studies and contribute to groundbreaking discoveries in related fields.

Please note that all services are for research use only. Not intended for any clinical use.

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