Gene: SERPINF2
Official Full Name: serpin family F member 2provided by HGNC
Gene Summary: This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05715 | SERPINF2 Knockout cell line (HeLa) | Human | SERPINF2 | 1:3~1:6 | Negative | Online Inquiry |
KO05716 | SERPINF2 Knockout cell line (HCT 116) | Human | SERPINF2 | 1:2~1:4 | Negative | Online Inquiry |
KO05717 | SERPINF2 Knockout cell line (A549) | Human | SERPINF2 | 1:3~1:4 | Negative | Online Inquiry |
SERPINF2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the SERPINF2 gene, which encodes the serpin peptidase inhibitor, clade F, member 2. This gene plays a critical role in the regulation of various biological processes, including the modulation of inflammatory responses and extracellular matrix remodeling. The knockout of SERPINF2 allows researchers to elucidate its functional significance in physiological and pathological contexts by utilizing these cell lines to study gene expression, protein interactions, and cellular behavior in the absence of SERPINF2.
The primary mechanism through which SERPINF2 exerts its effects involves the inhibition of serine proteases, affecting processes such as angiogenesis and tissue repair. By removing this inhibitory influence, researchers can investigate the downstream effects that may lead to enhanced or aberrant cellular activities, providing insights into conditions such as cancer, fibrosis, and cardiovascular diseases.
In a research setting, these SERPINF2 knockout cell lines are invaluable tools for understanding the complexities of various biological pathways. Their applications extend to genomics, proteomics, and drug discovery efforts, where identifying the roles of specific proteins in cell signaling and disease progression is critical.
Compared to traditional cell line models, SERPINF2 knockout cell lines offer the distinct advantage of providing a clean genetic background free from confounding variables associated with wild-type genes. This precision allows for clearer interpretation of experimental results and more reproducible data, making it an essential asset for both academic and clinical researchers.
The value of SERPINF2 Gene Knockout Cell Lines lies in their ability to enhance our understanding of disease mechanisms and therapeutic targets, essential for advancing scientific knowledge and developing innovative treatment strategies. As a leading provider of cutting-edge biological tools, our company is committed to supporting researchers and clinicians with high-quality products that facilitate groundbreaking discoveries in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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