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SERPINE2 Knockout Cell Lines

Gene: SERPINE2

Official Full Name: serpin family E member 2provided by HGNC

Gene Summary: This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09859 SERPINE2 Knockout cell line (HeLa) Human SERPINE2 1:3~1:6 Negative Online Inquiry
KO09860 SERPINE2 Knockout cell line (HCT 116) Human SERPINE2 1:2~1:4 Negative Online Inquiry
KO09861 SERPINE2 Knockout cell line (HEK293) Human SERPINE2 1:3~1:6 Negative Online Inquiry
KO09862 SERPINE2 Knockout cell line (A549) Human SERPINE2 1:3~1:4 Negative Online Inquiry

Background

SERPINE2 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to inhibit the expression of the SERPINE2 gene, which encodes a protein involved in various biological processes, including tissue remodeling and response to injury. By utilizing cutting-edge CRISPR/Cas9 technology, these cell lines are engineered to facilitate the study of SERPINE2's role in cellular mechanisms, such as apoptosis, inflammation, and tumorigenesis.

The key function of SERPINE2 Gene Knockout Cell Lines lies in their ability to allow researchers to systematically explore the biological implications of SERPINE2 deficiency. This is fundamental for investigations into its involvement in disease pathogenesis, particularly in cancer and neurodegenerative diseases. The knockout approach provides a clear mechanism to assess changes in cellular behavior, signaling pathways, and metabolic processes in the absence of SERPINE2, yielding insights that are crucial for both basic research and therapeutic development.

The scientific importance of these cell lines extends to their applications in drug discovery, biomarker identification, and preclinical research. By utilizing SERPINE2 knockout models, researchers can develop and validate targeted therapies that may enhance treatment efficacy by offering a deeper understanding of molecular interactions in disease contexts.

Compared to alternatives, such as RNA interference or transient approaches, the SERPINE2 Gene Knockout Cell Lines present a more stable, long-term solution with the capacity for clonal expansion, allowing for consistent experimentation and reproducibility. The precise genetic modification ensures that the specific effects observed can be confidently attributed to the absence of SERPINE2, thus providing a clear pathway for experimental validation.

For researchers and clinicians engaged in the advanced study of diseases where SERPINE2 is implicated, these knockout cell lines are invaluable. They empower scientists to conduct groundbreaking studies that may lead to novel therapeutic strategies, enhancing the overall understanding of key biological processes and disease mechanisms.

With extensive expertise in biotechnological innovations, our company is committed to providing high-quality, reliable products that facilitate cutting-edge research and therapeutic advancements. SERPINE2 Gene Knockout Cell Lines exemplify our dedication to supporting the scientific community's quest for knowledge and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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